What medicine is used for ankylosing spondylitis?

Written by Yang Ya Meng
Rheumatology
Updated on April 05, 2025
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The medication for ankylosing spondylitis mainly involves three aspects. The first is non-steroidal pain-relief medications, commonly including drugs like sustained-release diclofenac sodium tablets.

The second involves drugs that control the condition, commonly using medications like sulfasalazine and thalidomide.

The third, which is currently the most effective, involves treatment with biologics. Common biologics include tumor necrosis factor inhibitors. However, before using biologics, it is crucial to rigorously rule out complications such as hepatitis, tuberculosis, and tumors. Only after excluding these conditions should one consider using biologics.

Patients with ankylosing spondylitis should also pay attention to appropriate functional exercises in daily life to prevent the stiffening of spinal joints.

(Medications should be used under the guidance of a doctor, based on the specific situation.)

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Written by Li Jing
Rheumatology
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Does ankylosing spondylitis have a genetic component?

Ankylosing spondylitis is an autoimmune disease primarily affecting the axial joints. The onset is determined by both genetic and environmental factors, leading to the disease. This means that the disease exhibits a significant familial aggregation and genetic predisposition. If the parents have it, the incidence in their children is much higher than in others. However, it is definitely not a genetic disease; it just has familial clustering and genetic tendencies. If symptoms like stiffness in the neck or pain in the lower back intensify when at rest and decrease after activity, it is essential to use CT or MRI scans and test for HLA-B27 to check for damage or narrowing in the sacroiliac joints. Early diagnosis and early treatment are crucial to improve the prognosis of the condition.

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Written by Li Jing
Rheumatology
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What department should I go to for ankylosing spondylitis?

Ankylosing spondylitis is an idiopathic systemic disease primarily characterized by chronic inflammation of the axial joints, mainly involving the sacroiliac joint. The typical onset age ranges from 10 to 14 years, and it is more common in males. It is not hereditary, but there is a familial predisposition. If there is a family history, and localized pain or discomfort is present, especially if there is difficulty turning over at night, stiffness after waking or after prolonged sitting or standing, which eases with activity, it is important to be alert. This condition falls under rheumatic immune diseases, therefore, it should be managed by a rheumatology immunology department, not orthopedics.

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Written by Li Jing
Rheumatology
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What causes ankylosing spondylitis?

Ankylosing spondylitis is primarily an autoimmune disease affecting the axial joints, which may also manifest with extra-articular symptoms. In severe cases, deformities and stiffening of the spine can occur. The cause of the disease is attributed to the interactive effects of genetics and environmental factors, making it a multi-gene inherited disorder. However, for some individuals, it may also be related to infections such as Ureaplasma urealyticum, Shigella, Salmonella, and Escherichia coli in the urinary and genital tracts. These pathogens trigger the body's inflammatory immune response, resulting in tissue damage and contributing to the onset and progression of the disease. There is a notable familial aggregation in the occurrence of this disease.

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Written by Li Jing
Rheumatology
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What injections are used for ankylosing spondylitis?

Firstly, ankylosing spondylitis is an autoimmune disease primarily characterized by the destruction of axial joints, a chronic condition that can also manifest peripheral joint lesions. Currently, there are no definitive cures, meaning long-term medication is necessary to alleviate symptoms, control disease progression, delay joint deformity, reduce disability, and improve quality of life. This constitutes the overall goal of treatment. The preferred treatments are non-steroidal anti-inflammatory drugs (NSAIDs) and biologic agents. However, before using biologic agents, it is essential to complete routine blood tests, erythrocyte sedimentation rate, C-reactive protein, screenings for infectious diseases, and tuberculosis. After excluding infections, tuberculosis, and tumors, biologic agents can be administered. During the use of biologic agents, there is a risk of reduced immunity, making it easy to contract infections. Therefore, it is important to avoid getting cold, overwork, and to regularly recheck routine blood parameters, liver, and kidney functions.

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Written by Yang Ya Meng
Rheumatology
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How to control ankylosing spondylitis

The treatment of ankylosing spondylitis mainly consists of three parts: The first part is the use of non-steroidal anti-inflammatory drugs, such as sustained-release diclofenac sodium tablets; the second is the choice of disease control medications, which may include sulfasalazine or methotrexate tablets, especially for patients with peripheral joint pain, immunosuppressive drugs can be chosen. The most effective for ankylosing spondylitis are biologics, but before using biologics, it is necessary to exclude hepatitis, tuberculosis, and cancerous diseases, and the cost of biologics is relatively high. (Please use medications under the guidance of a professional physician and do not self-medicate.)