Angular cheilitis is a relatively common oral disease in daily life, often occurring during the autumn and winter seasons. This is mainly because during the dry weather of these seasons, patients lacking some trace elements or vitamins in their bodies can easily develop inflammation. The symptoms of angular cheilitis and herpes that occur in any season are quite similar, so many patients can easily get confused. The inducement of angular cheilitis is generally due to some patients' lack of vitamins and related to the weather, which can cause ruptures in the mucous membranes of the mouth corners and some dryness of the lips. As the condition worsens, symptoms such as swelling, erythema, ulcers, and rough skin appear in the area of the mouth corners. If caused by herpes, it results in blisters due to herpes virus infection.