Granulation tissue proliferation in otitis media indicates an active phase of inflammation. In clinical treatment, the first approach is medication, mainly using antibiotics and hormones, with both local and systemic applications of these drugs concurrently. Treatment usually lasts about two weeks. Generally, most granulations in otitis media are relatively small and can gradually shrink or even completely disappear with such medication. For granulations that fill the middle ear and tympanic cavity, if they cannot be reduced or controlled effectively through medication, then surgical intervention is necessary to remove the granulations in the middle ear cavity and thus treat the otitis media.