Will ferritin levels rise in cases of liver abscess? First, we need to understand the significance of ferritin testing. I can also tell you that ferritin does not necessarily increase during a liver abscess. The main form of iron in the body is present as serum ferritin. Clinically, its relationship with the aforementioned diseases is something we can discuss. The first one is related to iron-deficiency anemia. Generally, early stages of iron deficiency do not directly cause significant anemia, but they will lead to a reduction in iron stores. There are many methods for determining serum iron content in clinical laboratories, but none are as sensitive and reliable as serum ferritin. The second point is its relationship with tumors. Ferritin acts as a soluble tissue protein that stores iron in the body. It consists of a protein shell and an iron core, with the iron core having a strong capacity to bind and store iron, maintaining the supply of iron and the relative stability of hemoglobin. The liver is the site of synthesis of serum ferritin and also the organ that clears it. Normally, only a small amount is found in the serum, so during acute or chronic liver damage, or liver cancer, a noticeable increase occurs. Therefore, when liver abscesses affect liver function or cause destruction of liver cells, it can also lead to increased ferritin levels. However, in the early stages of a liver abscess, if treatment is proactive, ferritin levels might not increase.