The etiology of glioma

Written by Chen Yu Fei
Neurosurgery
Updated on September 21, 2024
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At present, there is no definitive conclusion regarding the specific causes of glioma. Clinically, it is generally considered the result of a combination of congenital genetic factors and acquired environmental factors. Usually, it is believed that there is a significant familial aggregation tendency in the family medical history of patients with gliomas, with a higher incidence of gliomas among family members. Additionally, acquired factors, such as severe cranial trauma followed by extensive proliferation of neuroglial cells, may induce incidents. Furthermore, severe intracranial infections, including unhealthy lifestyles, poor living environments, and the influence of radioactive materials, could potentially lead to the occurrence of gliomas.

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Written by Chen Yu Fei
Neurosurgery
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Early symptoms of glioma

For patients with glioma, in the early stages of the disease, symptoms often manifest as mild headaches, dizziness, nausea, and vomiting. The symptoms are usually mild and tolerable for patients, and most patients do not pay enough attention, which can easily lead to missed and misdiagnosis. However, as the tumor volume increases, the patient's symptoms of headache, dizziness, and other discomforts gradually worsen, and may even show episodic outbreaks and a persistent worsening state. In addition to headaches and dizziness, some patients also exhibit significant motor dysfunction, exhibiting symptoms such as hemiplegia and aphasia. Patients with severe conditions may even experience widespread intracranial pressure increase, and life-threatening conditions due to the induction of brain herniation.

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Written by Chen Yu Fei
Neurosurgery
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Is glioma a terminal illness?

Glioblastoma is not an incurable disease. Patients with glioblastoma have a type of malignant tumor that tends to grow rapidly. These tumors often adhere to surrounding brain tissue in the early stages, making complete surgical removal difficult. If any glioma cells remain after surgery, the tumor tissue will gradually grow over time. Thus, patients with glioblastoma are prone to recurrence, but it is not an incurable disease. If early detection and surgical removal can be achieved, and supplemented by radiotherapy and chemotherapy, it can maximize the therapeutic effects of the surgery, thereby effectively improving the prognosis and delaying the progression of the disease. This approach can relatively extend the patient's lifespan, and some patients may even achieve long-term survival.

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Written by Chen Yu Fei
Neurosurgery
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Clinical manifestations of glioma

For patients with glioma, as it is a malignant tumor with a rapid growth rate, they may exhibit severe symptoms at the early stage of the disease, including severe headaches, dizziness, nausea, vomiting, loss of appetite, poor mental state, poor sleep quality at night, frequent insomnia and nightmares, and easy waking up. As the tumor increases in size, it often causes an increase in intracranial pressure. In severe cases, this may lead to optic disc edema, decreased vision, and visual field defects. Additionally, some patients may experience impairment in motor functions, manifesting as hemiplegia, and in some cases, aphasia. It is advised to undergo surgery in the early stages, followed by radiotherapy and chemotherapy.

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Written by Chen Yu Fei
Neurosurgery
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What are the symptoms of glioma?

Patients with gliomas often exhibit a range of symptoms including significant headaches, dizziness, nausea, and vomiting. As the tumor grows, it typically leads to an evident increase in intracranial pressure. Besides the original symptoms, some patients may also experience marked declines in vision, visual field deficits, and papilledema. The growth of the tumor inevitably compresses surrounding tissues, nerves, and blood vessels, leading to a variety of symptoms of neurological damage, such as noticeable hemiplegia, aphasia, and even abnormal sensations in one side of the body, characterized by numbness, pain, and a pins-and-needles sensation.

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Written by Chen Yu Fei
Neurosurgery
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Principles of Treatment for Glioma

For patients with glioma, the primary treatment method is still to surgically remove the tumor, followed by postoperative radiotherapy, chemotherapy, and other related treatments. The main treatment principle is to detect, diagnose, and treat early. During surgery, the tumor should be removed as completely as possible, and it is advisable to receive postoperative radiotherapy and chemotherapy early to effectively consolidate the surgical treatment effects. This helps to kill tumor cells to the greatest extent, slow down the probability and timing of tumor recurrence, and extend the patient's lifespan as much as possible. Therefore, for patients with glioma, it is recommended to choose to seek surgical treatment at well-known, top-tier hospitals locally.