Is pheochromocytoma a cancer?

Written by Chen Yu Fei
Neurosurgery
Updated on September 02, 2024
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Pheochromocytoma is not a cancer. It is a special type of tumor tissue that usually originates from the neuroectodermal chromaffin tissue. It can secrete catecholamines. Based on the specific origins of the tumor cells, it can be divided into types such as parasympathetic, paraganglioma, sympathetic, and ganglioneuroma. Most often, it presents with long-term hypertension, which can cause damage to the heart, brain, and kidneys due to prolonged hypertension, or severe increases in blood pressure can lead to hypertensive brain hemorrhage, thereby endangering the patient's life. Early treatment is often necessary.

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Written by Chen Yu Fei
Neurosurgery
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What tests are used for pheochromocytoma?

For pheochromocytoma, it is usual to perform both qualitative and localization diagnoses. The qualitative diagnosis is generally based on the measurement of catecholamines and their metabolites in the patient's blood and urine. Localization diagnosis is more commonly determined through methods such as CT scans, MRI, and ultrasound to pinpoint the specific location of the pheochromocytoma, facilitating surgical treatment. Most patients achieve satisfactory results from surgery. Additionally, treatment may include the use of antihypertensive drugs. With combined treatment, most patients can achieve satisfactory results. It is recommended to seek treatment at a well-known tertiary hospital locally.

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Written by Chen Yu Fei
Neurosurgery
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Causes of hypotension in pheochromocytoma

For cases of hypotension occurring in pheochromocytoma, it is most commonly seen after the surgical removal of the tumor. At this point, the concentration of catecholamines in the blood may significantly decrease, leading to a marked reduction in effective circulating blood volume, and thus causing hypotension. This situation is relatively common after surgery for pheochromocytoma. Usually, after surgical treatment and removal of the tumor, it is important to promptly discontinue the use of receptor blockers in patients and to appropriately replenish blood volume to effectively maintain central venous pressure. This approach can generally counteract the reduction in catecholamine levels caused by surgery, which leads to hypotension.

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Written by Chen Yu Fei
Neurosurgery
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The manifestations of pheochromocytoma crisis

For patients with pheochromocytoma, during a crisis, it generally manifests as a sudden increase in the patient's blood pressure, which can rise to above 200-300 mmHg. Additionally, the patient experiences severe headaches and dizziness, severe nausea and vomiting. Some patients may experience significant discomfort and tachycardia, arrhythmias. Some patients also suffer from abdominal or chest pain, labored breathing, and difficulty breathing, and even blurred vision. In severe cases, the excessively high blood pressure can lead to hypertensive cerebral hemorrhage or other unexpected cardiovascular and cerebrovascular diseases. The patient’s vital signs are extremely unstable, often accompanied by multiple organ dysfunction or failure.

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Endocrinology
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What should I do if a pheochromocytoma ruptures?

When a pheochromocytoma ruptures, it is advised that the patient immediately goes to the emergency department of the hospital for relevant examinations to confirm the diagnosis and to immediately control the blood pressure to a relatively stable and safe level. After a comprehensive evaluation, the urology department will perform emergency surgical removal to save the patient's life. Spontaneous rupture and bleeding of adrenal pheochromocytoma is quite rare. The possible reasons might be long-term hypertension leading to poor vascular function, or rapid tumor growth with high capsule pressure causing vascular rupture. Additionally, intense exercise, excessive fatigue, and transient increases in blood pressure could also be triggering factors.

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Written by Li Pei
Neurosurgery
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How to test for pheochromocytoma?

Pheochromocytoma is a tumor that occurs in the adrenal gland. The tumor secretes a large amount of catecholamines, causing an increase in blood pressure. Diagnostic tests for pheochromocytoma can include a CT scan and MRI of the adrenal glands to confirm the presence of any adrenal mass. Additionally, ultrasound can also be used as an auxiliary test to help confirm the diagnosis. It is also advisable to check the levels of catecholamines in the blood and urine to further confirm the presence of an adrenal pheochromocytoma.