Nasopharyngeal carcinoma symptoms

Written by Deng Bang Yu
Otolaryngology
Updated on July 02, 2025
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Nasopharyngeal carcinoma is a malignant tumor located in the nasopharyngeal region, and it is primarily squamous cell carcinoma clinically. The clinical symptoms of nasopharyngeal carcinoma mainly include bloody nasal discharge. Examination can reveal malignant neoplasms in the nasopharyngeal area. As the tumor grows, it can press on the posterior nasal aperture causing nasal congestion, and compression of the pharyngeal opening of the eustachian tube may lead to symptoms such as ear fullness and tinnitus. The tumor may spread to the lymph nodes in the neck, causing neck masses, and destroy adjacent tissue structures. For instance, if it spreads to the brain, it can cause brain pain, compress ocular tissues, and lead to symptoms like painful eye bulging.

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How should nasopharyngeal carcinoma be examined?

Nasopharyngeal carcinoma is a relatively common otolaryngological disease and is also considered as one of the common head and neck malignant tumors. For diagnosis, an initial examination that can be conducted is nasopharyngoscopy. Through nasopharyngeal endoscopy, most patients can see changes in the nasopharynx due to new growths, which suggests considering a pathological biopsy test. This helps in obtaining a pathological diagnosis and allows for analysis and typing of the pathology. At the same time, imaging exams are necessary, with nasopharyngeal CT or MRI being commonly used. Additionally, it is recommended to test for the Epstein-Barr virus, as some patients’ condition could be a result of a long-term infection with this virus.

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Can nasopharyngeal carcinoma be cured?

Nasopharyngeal carcinoma cannot be completely cured, as it is a malignant tumor, and malignant tumors cannot be completely cured worldwide. Nasopharyngeal carcinoma refers to the malignant tumors that occur at the top or lateral walls of the nasopharynx. The common clinical cause is viral infection, most commonly associated with the Epstein-Barr virus, causing dryness, pain, and itching in the nasopharynx, along with backflow, blood in sputum, and swollen lymph nodes in the neck. Patients need to undergo a detailed examination with an electronic nasopharyngoscope and a CT scan of the nasopharynx for diagnosis. If an abnormal neoplasm is found, local pathological treatment is required. Once confirmed as malignant, local radiation therapy, chemotherapy, and surgical treatment are also needed. After surgery, patients need to undergo regular follow-up examinations, and further treatment may be required if abnormal proliferation is found.

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Can nasopharyngeal cancer be cured?

Nasopharyngeal carcinoma is a relatively common type of head and neck malignant tumor. Currently, radiation therapy is commonly used for treatment. Depending on the severity of the patient's condition, some patients may also need to combine chemotherapy. The specific treatment effectiveness varies from individual to individual, and some patients can achieve clinical cure. For early-stage nasopharyngeal carcinoma, the treatment effectiveness is relatively good, and the clinical cure rate is comparatively high. For mid to late-stage nasopharyngeal carcinoma, the treatment becomes more challenging, and the treatment effectiveness is relatively poorer. After treatment, regular check-ups are required to monitor the recovery of the condition. If no recurrence or distant metastasis is found five years after treatment, the patient is considered clinically cured.

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What are the symptoms of late-stage nasopharyngeal carcinoma?

Nasopharyngeal cancer is a common malignancy in otolaryngology, primarily located in the nasopharyngeal area. In advanced stages, nasopharyngeal cancer manifests symptoms in two main aspects. One involves symptoms directly caused by the cancer or its metastasis, typically presenting as increased nasal masses, enlarged cervical lymph nodes, severe headaches, decreased hearing, and bleeding in the nasal area due to tumor cells or tissue eroding the internal carotid artery. Additionally, there is a foul smell from the nasopharyngeal area. The second aspect relates to systemic symptoms due to the growth of nasopharyngeal cancer, leading to poor overall nutritional status and cachexia, characterized by extreme emaciation. There is also the potential for distant metastasis of the tumor cells, presenting symptoms in the corresponding areas.

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What causes nasopharyngeal carcinoma?

The specific cause of nasopharyngeal carcinoma, a type of malignant tumor, is currently unclear, but it is considered to be related to some high-risk factors that may lead to the occurrence of nasopharyngeal cancer. Firstly, there are cases of EB virus infections in the nasopharyngeal area. The long-term stimulation of the nasopharyngeal mucosa by this virus leads to hyperplasia of the mucosa, which can become malignant and eventually form nasopharyngeal cancer. Additionally, some clinical studies suggest that the occurrence of nasopharyngeal carcinoma is related to genetic factors, indicating a genetic predisposition to nasopharyngeal carcinoma, which leads to its development. Furthermore, some considerations involve external carcinogenic factors affecting the nasopharyngeal area, such as long-term smoking or environmental air pollution, which can also lead to a high incidence of nasopharyngeal cancer.