Nasopharyngeal carcinoma is a relatively common otorhinolaryngological disease with various clinical symptoms. The more common symptoms include nasal congestion, runny nose, and bloody nasal discharge. Some patients may experience headaches, which could potentially be due to intracranial metastasis of the nasopharyngeal carcinoma or nerve invasion, causing neuropathic pain. The specific characteristics of the headache mainly manifest as persistent and severe pain. Although pain relief medications can temporarily alleviate the symptoms, the relief usually does not last long. After the effects of the medication wear off, the pain may recur. Moreover, this condition is generally challenging to treat, and treatment outcomes may not be ideal.