What is nasopharyngeal carcinoma?

Written by Li Rui
Otolaryngology
Updated on September 25, 2024
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Nasopharyngeal carcinoma is a relatively common malignant tumor in the nasopharyngeal area, and the main pathological type is predominantly squamous carcinoma, most of which are poorly differentiated squamous carcinomas, constituting the most common malignant tumor in the nasopharyngeal area. Currently, the primary treatment option is radiotherapy, which is the most important; some patients may need to consider concurrent or adjuvant chemotherapy. If drug and radiotherapy treatments are ineffective, or if there is cervical lymph node metastasis, and for some patients where chemoradiotherapy fails with residual lesions, surgery may be considered. However, currently, the surgical treatment approach is generally not very mature and is somewhat controversial, thus it requires treatment at major hospitals.

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What should I do if nasopharyngeal carcinoma causes vomiting?

Patients with nasopharyngeal carcinoma who exhibit vomiting should first determine the cause of the vomiting. For instance, if vomiting is due to the gastrointestinal reactions caused by radiotherapy and chemotherapy, medications such as serotonin receptor antagonists, corticosteroids, and NK-1 receptor blockers should be used to alleviate the side effects of the treatment. Additionally, nasopharyngeal carcinoma patients might experience projectile vomiting due to brain metastasis, which results in increased intracranial pressure. It is essential first to confirm the presence of brain metastasis through CT and MRI scans of the head. If brain metastasis is confirmed, localized treatment such as radiotherapy should be administered. Medications like mannitol and glycerol fructose should be used concurrently to reduce intracranial pressure and relieve the projectile vomiting. (Please use medications under the guidance of a doctor.)

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Do people with nasopharyngeal carcinoma lose weight?

Some patients with nasopharyngeal carcinoma may experience weight loss, but individual differences exist. This is somewhat related to the condition itself as well as to the individual's resistance and their baseline physical fitness. If the condition is detected early and the clinical symptoms are not particularly obvious, most patients will not show significant weight loss, and many people may not have noticeable symptoms. If the condition is severe, and diet and nutrition are not properly managed in a timely manner, patients may experience weight loss, especially in advanced stages of the illness. This can result in a cachectic-like state, which poses greater challenges for treatment. It is necessary to seek medical attention promptly, assess the physical condition, and consider the need for radiotherapy and chemotherapy.

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Can you smoke with nasopharyngeal carcinoma?

Patients with nasopharyngeal carcinoma should not smoke, as tobacco is a very certain carcinogenic factor. There is a significant correlation between the high incidence of nasopharyngeal carcinoma and long-term smoking. Therefore, if patients do not eliminate carcinogenic factors, nasopharyngeal carcinoma is likely to recur or metastasize after curative surgery or radiotherapy. Additionally, patients with nasopharyngeal carcinoma need to undergo treatment strategies such as surgery, radiotherapy, and chemotherapy. Continuous smoking can affect the effectiveness of these anti-tumor treatments and is detrimental to the patient's recovery. Furthermore, smoking can also lead to other types of malignant tumors. Therefore, it is not advisable for patients with nasopharyngeal carcinoma to smoke. It is also recommended that patients improve other unhealthy lifestyle habits, such as long-term alcohol consumption, a high-fat diet, and the consumption of pickled or fried foods, as these are also causes of high nasopharyngeal carcinoma incidence and should be avoided.

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How should nasopharyngeal carcinoma be examined?

Nasopharyngeal carcinoma is a relatively common otolaryngological disease and is also considered as one of the common head and neck malignant tumors. For diagnosis, an initial examination that can be conducted is nasopharyngoscopy. Through nasopharyngeal endoscopy, most patients can see changes in the nasopharynx due to new growths, which suggests considering a pathological biopsy test. This helps in obtaining a pathological diagnosis and allows for analysis and typing of the pathology. At the same time, imaging exams are necessary, with nasopharyngeal CT or MRI being commonly used. Additionally, it is recommended to test for the Epstein-Barr virus, as some patients’ condition could be a result of a long-term infection with this virus.

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Symptoms of nasopharyngeal carcinoma

Nasopharyngeal carcinoma is a malignant tumor that occurs in the nasopharyngeal area. Typically, nasopharyngeal carcinoma often occurs at the top of the nasopharynx and on the lateral walls of the rhinitis. In the early stages, patients may experience nasal congestion, a runny nose, and upon waking, they might have yellow or bloody discharge. In severe cases, the patient may also experience symptoms such as hearing loss, tinnitus, and ear fullness. If a patient exhibits the aforementioned symptoms, they should first visit a hospital for an electronic nasopharyngoscopy. This can reveal the presence of cauliflower-like neoplasms or ulcers in any part of the nasopharynx. If such findings are observed, a local pathology biopsy is needed. If it is confirmed to be a malignant tumor of the nasopharynx, relevant radiotherapy and chemotherapy treatments are required. Additionally, the patient should also undergo regular systemic examinations to check for distant metastases.