How is nasopharyngeal carcinoma diagnosed?

Written by Li Rui
Otolaryngology
Updated on September 09, 2024
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The examination of nasopharyngeal carcinoma is mainly divided into two major categories. The first category is imaging examinations, and the second category is pathological biopsy tests. Imaging examinations primarily involve performing a CT or MRI of the nasopharyngeal area to determine the scope of the cancerous changes in the nasopharynx, which is quite helpful for clinical staging and typing. It also plays a role in designing targeted therapy for subsequent radiation treatment. Pathological testing is an important means for diagnosing nasopharyngeal carcinoma. Generally, it requires a nasopharyngoscopy. If cancerous changes are suspected during the nasopharyngoscopy, a pathological biopsy can be taken simultaneously. After the biopsy, the specific differentiation degree and type of cancer can be determined. Then, in conjunction with the imaging examinations, a plan for radiotherapy and chemotherapy can be formulated.

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Can nasopharyngeal carcinoma be treated with surgery?

Nasopharyngeal cancer is a malignant tumor in the nasopharynx, which is mainly found in coastal and Guangdong areas, and is more common among Mongoloid races. The treatment methods for nasopharyngeal cancer include radiotherapy, chemotherapy, and combined chemoradiotherapy. If the tumor does not disappear after combined chemoradiotherapy and is insensitive to drugs, surgery can be considered. Surgery is not the first-line treatment option for nasopharyngeal cancer; the first-choice treatments are radiotherapy and combined chemoradiotherapy, which are very effective and have a high five-year survival rate. If the cancer is insensitive to radiation and drugs, surgical treatment can be an option in such cases.

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Written by Deng Bang Yu
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What are the symptoms of nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a malignant, space-occupying lesion in our nasopharynx. Clinically, the initial symptoms are those of the nasopharynx, manifesting as discomfort in the nasopharyngeal area, or blood in nasal discharge when sniffling. As the nasopharyngeal carcinoma tissue enlarges, it can block the posterior nasal apertures, leading to nasal congestion, rapid breathing, and difficulty in breathing. The tumor tissue pressing on our Eustachian tube can cause secretory middle ear infections. The metastasis of nasopharyngeal carcinoma cells to our cervical lymph nodes causes swelling of these lymph nodes. Destruction of the cranial structure by nasopharyngeal carcinoma tissues presents symptoms such as headaches. There are also other symptoms, mainly due to the spread of nasopharyngeal carcinoma throughout the body or its metastasis to other parts causing corresponding symptoms.

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Written by Li Rui
Otolaryngology
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Does nasopharyngeal carcinoma cause coughing?

Nasopharyngeal carcinoma is a relatively common type of malignancy in the head and neck area, and a small number of patients may experience coughing, mainly because the secretions from the nasopharyngeal carcinoma can enter the throat through the posterior nasal aperture, causing an irritative cough. Overall, the occurrence of this symptom is relatively rare. More common symptoms include nasal congestion, bloody nasal discharge, with some patients experiencing headaches or enlarged cervical lymph nodes, and changes in vision. After diagnosis, it is recommended to visit the otolaryngology or oncology departments promptly to assess the severity of the condition. Most patients need to consider radiotherapy and chemotherapy, and regular follow-ups are necessary to monitor treatment outcomes.

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Can nasopharyngeal cancer be cured?

A portion of nasopharyngeal carcinoma patients can meet the criteria for clinical cure. It largely depends on the specific staging and type of the cancer. Patients with higher differentiation and earlier stages, especially stages one and two, tend to have better treatment outcomes. Currently, radiation therapy is the primary treatment, and some patients may also need to undergo chemotherapy. Overall, chemotherapy is quite effective for most patients. However, whether clinical cure can be achieved primarily depends on the extent of the disease and individual differences. Some people respond better to radiotherapy and chemotherapy, which in turn increases their chances of clinical cure. The five-year survival rate is considered the most important indicator.

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How is nasopharyngeal carcinoma diagnosed?

Nasopharyngeal carcinoma is a malignant, occupying lesion that occurs in the nasopharyngeal area, and clinically it is mainly squamous cell carcinoma. Relatively speaking, although this tumor is malignant, its degree of malignancy is relatively low, especially when compared to liver cancer, lung cancer, and other malignant tumors. The definitive diagnosis of any tumor primarily relies on histopathological diagnosis, which means that pathological examination is the gold standard. In the case of nasopharyngeal carcinoma, we can make a pathological examination by using nasopharyngeal biopsy tissue with forceps under nasendoscopy. If cancer cells are found, then it is essentially confirmed. Of course, other examination methods, such as CT and MRI, are also helpful in diagnosing nasopharyngeal carcinoma and determining whether there are any metastases.