Causes of Nasopharyngeal Carcinoma

Written by Yao Jun
Otolaryngology - Head and Neck Surgery
Updated on September 17, 2024
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Nasopharyngeal carcinoma is a highly prevalent malignant tumor in China, especially common in the Guangdong and Guangxi regions, as well as other coastal areas including Hunan, Fujian, and Jiangxi. These regions are among the highest incidence areas for nasopharyngeal carcinoma worldwide. The incidence rate in males is three times that of females, with the age group of 40 to 50 years being particularly at risk. The occurrence of nasopharyngeal carcinoma is associated with genetic, viral, and environmental factors, exhibiting racial and familial patterns. In areas like Guangzhou and the Pearl River Delta, it is possible for five out of nine people in the same family to have nasopharyngeal carcinoma. Infection with the Epstein-Barr virus is also one of the causes of nasopharyngeal carcinoma, in addition to environmental factors. Areas with low trace elements in rice and water, as well as low fluoride levels, are prone to higher incidences of this cancer. Patients with nasopharyngeal carcinoma typically have higher fluoride levels in their hair, and nitrites are also one of the major contributing factors to the condition.

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Characteristics of headaches caused by nasopharyngeal carcinoma

Nasopharyngeal carcinoma is a relatively common otorhinolaryngological disease with various clinical symptoms. The more common symptoms include nasal congestion, runny nose, and bloody nasal discharge. Some patients may experience headaches, which could potentially be due to intracranial metastasis of the nasopharyngeal carcinoma or nerve invasion, causing neuropathic pain. The specific characteristics of the headache mainly manifest as persistent and severe pain. Although pain relief medications can temporarily alleviate the symptoms, the relief usually does not last long. After the effects of the medication wear off, the pain may recur. Moreover, this condition is generally challenging to treat, and treatment outcomes may not be ideal.

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Is nasopharyngeal carcinoma contagious?

Nasopharyngeal carcinoma currently has no definite transmissibility, and the exact cause of nasopharyngeal cancer is not particularly clear. Clinical studies have shown that there is a certain relationship between nasopharyngeal carcinoma and EB virus infection, but it may also be related to other factors, such as familial heredity or living environment. Exposure to radioactive or chemical substances may also have a certain impact. Currently, there is no evidence to suggest that there is genetic or absolute contagion. Overall, in terms of treatment, radiotherapy is mainly used, and some patients need to be combined with chemotherapy. Generally, the five-year survival rate is relatively high among early-stage patients. If the disease staging is later and the differentiation is poor, the treatment difficulty and treatment effect are relatively worse.

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Can nasopharyngeal cancer be cured?

Nasopharyngeal carcinoma is a relatively common type of head and neck malignant tumor. Currently, radiation therapy is commonly used for treatment. Depending on the severity of the patient's condition, some patients may also need to combine chemotherapy. The specific treatment effectiveness varies from individual to individual, and some patients can achieve clinical cure. For early-stage nasopharyngeal carcinoma, the treatment effectiveness is relatively good, and the clinical cure rate is comparatively high. For mid to late-stage nasopharyngeal carcinoma, the treatment becomes more challenging, and the treatment effectiveness is relatively poorer. After treatment, regular check-ups are required to monitor the recovery of the condition. If no recurrence or distant metastasis is found five years after treatment, the patient is considered clinically cured.

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What are the symptoms of late-stage nasopharyngeal carcinoma?

Nasopharyngeal cancer is a common malignancy in otolaryngology, primarily located in the nasopharyngeal area. In advanced stages, nasopharyngeal cancer manifests symptoms in two main aspects. One involves symptoms directly caused by the cancer or its metastasis, typically presenting as increased nasal masses, enlarged cervical lymph nodes, severe headaches, decreased hearing, and bleeding in the nasal area due to tumor cells or tissue eroding the internal carotid artery. Additionally, there is a foul smell from the nasopharyngeal area. The second aspect relates to systemic symptoms due to the growth of nasopharyngeal cancer, leading to poor overall nutritional status and cachexia, characterized by extreme emaciation. There is also the potential for distant metastasis of the tumor cells, presenting symptoms in the corresponding areas.

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Is a fever in nasopharyngeal carcinoma a sign of deterioration?

Patients with nasopharyngeal carcinoma may exhibit fever in a clinical setting. This fever can partially be due to the worsening of the carcinoma itself. However, not all cases are due to progression of the disease; some are caused by infections and other factors. For example, after receiving anti-tumor treatments such as radiotherapy and chemotherapy, patients with nasopharyngeal carcinoma may experience a decrease in white blood cells, making them highly susceptible to infections, which can then manifest as fever. Additionally, patients with nasopharyngeal carcinoma may have weakened immune systems, making them prone to infections and fevers. As the nasopharyngeal carcinoma progresses, it can release abnormal hormones, forming endogenous fever-inducing agents, leading to clinical manifestations of fever. Generally, this type of fever is referred to as tumor fever, which is often related to the progression of the disease. Tumor fever typically requires anti-tumor treatment for effective relief.