With the continuous advancement of organ function support technology in the ICU, or Intensive Care Unit, the mortality rate of severe pancreatitis has been declining year by year. Currently, the mortality rate of acute severe pancreatitis has significantly decreased compared to several decades ago, mainly due to the continuous progress in ICU organ function support technologies and some advancements in minimally invasive vascular interventional treatment methods. Severe pancreatitis generally goes through two stages during its progression. The first stage is called the organ function impairment period, which occurs within one to two weeks after the onset of severe pancreatitis. Due to intense inflammatory and anti-inflammatory responses in the body, multiple organ functions are compromised. The ICU currently has very comprehensive organ function support measures that can help most patients survive through stages of organ failure such as respiratory failure, acute renal failure, septic shock, liver dysfunction, and coagulation abnormalities. The second stage is the intra-abdominal infection period, where severe pancreatitis leads to intra-abdominal infections. Now, with the use of minimally invasive techniques in vascular interventional medicine, fluid accumulation in the abdominal cavity can be punctured and drained under ultrasound and CT guidance, draining infectious lesions and significantly lowering the mortality rate for this group of patients. Therefore, the current overall mortality rate for acute severe pancreatitis is not very high. Severe acute pancreatitis can be fully treated through aggressive organ function support and treatment of intra-abdominal infections.