Patients with early-stage pancreatic cancer generally do not exhibit many symptoms, as the tumors are relatively small. Clinically, many patients may experience intermittent mild abdominal pain that does not affect their daily lives. A small number of early-stage patients may exhibit symptoms of general fatigue, mild loss of appetite, nausea, mild acid reflux, or other symptoms of indigestion. Additionally, a few patients in the early stages may experience intermittent episodes of diarrhea. Because these symptoms are not distinctive, patients rarely seek medical attention early. When symptoms like significant epigastric pain and jaundice become apparent, it often indicates that the pancreatic cancer has progressed to a more advanced stage.