Early symptoms and manifestations of pancreatic cancer

Written by Yan Chun
Oncology
Updated on February 08, 2025
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Pancreatic cancer is a type of malignant tumor that has seen an increase in incidence in recent years. The early symptoms and signs of pancreatic cancer include the following: many patients experience abdominal pain, which often radiates to the shoulder and back. Additionally, some patients with early-stage pancreatic cancer may develop jaundice in the skin and mucous membranes, and some may even exhibit bleeding spots. Moreover, some patients with early-stage pancreatic cancer may show symptoms of indigestion, experiencing repeated belching, nausea, and loss of appetite. Furthermore, the symptoms of early-stage pancreatic cancer are generally not typical because the tumor is located deep within the body and is small, hence it does not invade surrounding tissues. Therefore, the clinical symptoms are neither severe nor diverse.

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Written by Liu Liang
Oncology
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What are the symptoms of pancreatic cancer?

The most common symptom of pancreatic cancer is abdominal pain, typically pain in the upper abdomen. Jaundice is also common, especially in cancers of the head of the pancreas, where it is the most frequent clinical manifestation. Upon physical examination, some patients may have a palpable mass in the upper abdomen. Other common symptoms include gastrointestinal issues, such as nausea, vomiting, a feeling of fullness after eating, and a decrease in appetite. These are some of the symptoms related to the digestive tract.

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Written by Wu Hai Wu
Gastroenterology
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How to deal with lower limb edema in advanced pancreatic cancer?

In late-stage pancreatic cancer, bilateral lower extremity edema should be considered possibly due to hypoalbuminemia, which leads to edema in both legs. It is also possible that cancer emboli in late-stage pancreatic cancer block the venous system, causing impaired venous return and resulting in bilateral lower extremity edema. To determine the specific cause, it is necessary to complete ultrasonographic examinations of the blood vessels in the lower limbs, as well as liver function tests, complete blood count, and others. After clarifying the diagnosis, appropriate treatment measures should be taken based on the different causes. For example, if the edema is caused by hypoalbuminemia, active supplementation with albumin and diuretics, among other treatments, is required. (Note: The use of medications should be carried out under the guidance of a professional doctor.)

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Written by Yan Chun
Oncology
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How is pancreatic cancer caused?

Currently, there is no consensus in clinical practice regarding the causes of pancreatic cancer, but some studies have found that certain factors contribute to its high incidence. For example, patients with diabetes have a higher incidence of pancreatic cancer compared to those without diabetes, and having chronic pancreatitis and other diseases also leads to a higher occurrence of pancreatic cancer. Additionally, factors such as genetic mutations are also associated with the development of pancreatic cancer. Some research has found that there is a certain correlation between genetic factors and the occurrence of pancreatic cancer. Once pancreatic cancer develops, it leads to a variety of symptoms in clinical settings.

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Written by Yan Chun
Oncology
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Early symptoms and signs of pancreatic cancer

Pancreatic cancer is a malignant tumor of the digestive system and does not have a high clinical incidence rate. Early symptoms of pancreatic cancer are not typical; some patients experience abdominal pain, primarily a persistent episodic pain that may radiate to the shoulder and back. Additionally, early-stage pancreatic head cancer patients may exhibit jaundice, often caused by obstructive jaundice due to tumor compression. Besides this, patients may also have clay-colored stools or urine the color of strong tea. Beyond these symptoms, early-stage patients exhibit no other signs. When typical clinical manifestations occur, they are generally indicative of mid to late-stage pancreatic cancer. Precursors to pancreatic cancer include persistent hidden pain in the shoulder or a stiff pain in the back. This continuous pain, often caused by the invasion of the abdominal nervous plexus, results in radiating pain.

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Written by Liu Liang
Oncology
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What does pancreatic cancer ascites mean?

When pancreatic cancer causes ascites, particularly a large amount, we can collect the ascites to search for cancer cells. This generally indicates peritoneal metastasis, or metastasis above the liver which can also cause substantial ascites. In such cases, it typically signifies that the disease has progressed to a late stage, classified as stage IV. Patients in this category are unable to undergo surgery and their treatment primarily involves chemotherapy. If the patient's overall condition is good, chemotherapy can be chosen. If the patient's condition is relatively poor, targeted therapy or oral anti-angiogenesis medications may be selected to control the pancreatic cancer and manage the tumor. If the patient's condition is particularly poor, the approach involves placing a peritoneal drainage tube to remove the ascites and providing the best possible symptomatic supportive care.