What is the best treatment for duodenal ulcers?

Written by Si Li Li
Gastroenterology
Updated on December 30, 2024
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The main symptoms of duodenal ulcer include upper abdominal bloating, belching, acid reflux, nausea, vomiting, heartburn, poor appetite, and indigestion. A duodenal ulcer can be diagnosed through a gastroscopy, which reveals the presence of an ulcer in the duodenum. The primary cause of duodenal ulcers is infection by Helicobacter pylori, hence a Carbon-14 breath test is recommended to confirm the presence of H. pylori infection. Roughly 90%-100% of patients with duodenal ulcers are infected with H. pylori. Another common cause is the digestion of the stomach itself by stomach acid and pepsin. Treatment primarily involves eradicating H. pylori, suppressing acid, protecting the stomach, enhancing gastric motility, and protecting the gastric mucosa, with the treatment duration being about six weeks.

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Written by Jiang Guo Ming
Gastroenterology
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Can duodenal ulcers be cured?

Duodenal bulb ulcers are definitely treatable. Treatment is mainly through medication, with the specific approach depending on the presence of Helicobacter pylori infection. If there is no Helicobacter pylori infection, treatment primarily focuses on symptomatic relief using traditional medicines such as proton pump inhibitors, like omeprazole and lansoprazole. If Helicobacter pylori infection is present, antibacterial treatment is generally needed, using either triple or quadruple antibiotic therapy; triple therapy consists of a proton pump inhibitor plus two antibiotics, and adding bismuth forms quadruple therapy. One treatment cycle lasts two weeks, and after completing medication, Helicobacter pylori can be rechecked in one month. Additionally, it's important to maintain good dietary and living habits. If recurrent duodenal bulb ulcers cause bleeding at night, surgical treatment can typically be considered.

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Written by Wu Hai Wu
Gastroenterology
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What position should be taken for duodenal ulcer hematemesis?

Patients with duodenal ulcers, if vomiting blood occurs, are advised to slightly elevate their lower limbs, position their heads lower, and lie on their side. Because when patients with duodenal ulcers vomit blood, it indicates a relatively large amount of bleeding. Elevating the lower limbs slightly can effectively promote the return of blood from the lower limbs, ensuring the blood supply to vital organs, and lying on the side helps prevent the possibility of choking following vomiting. Once vomiting blood due to a duodenal ulcer occurs, an urgent gastroscopy is required, and hemostatic treatment should be carried out under gastroscopy.

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Written by Si Li Li
Gastroenterology
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What are the symptoms of duodenal ulcers?

The main symptoms of duodenal ulcers include upper abdominal bloating, burping, acid reflux, nausea, vomiting, poor appetite, and indigestion. The characteristic of the upper abdominal pain associated with duodenal ulcers is that the pain intensifies when hungry and decreases after eating. In terms of treatment, the main approach includes acid suppression to protect the stomach, promoting gastric motility, and protecting the gastric mucosa, with the treatment course lasting about six weeks. Additionally, a Carbon-14 breath test is necessary to determine the presence of Helicobacter pylori infection, as Helicobacter pylori has been confirmed as the most important cause of peptic ulcers. If the Helicobacter pylori infection is positive, a 14-day treatment targeting Helicobacter pylori is required, using a regimen of a proton pump inhibitor, two antibiotics, and a bismuth agent.

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Written by Wu Hai Wu
Gastroenterology
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Is duodenal ulcer bleeding a sign of cancerous change?

Duodenal ulcer bleeding does not indicate cancerous changes. The duodenal area is relatively thin, so once a duodenal ulcer occurs, it is more likely to lead to complications such as ulcer bleeding and perforation. If vomiting blood occurs with a duodenal ulcer, it indicates that the patient with the duodenal ulcer has a bleeding complication. In terms of treatment, it is first necessary to complete an endoscopic examination, which can include endoscopic hemostasis; secondly, proton pump inhibitors should be used to suppress the secretion of stomach acid and increase the pH level in the stomach; additionally, treatments that protect the stomach lining, such as aluminum hydroxide and magnesium carbonate, should be used. (Medication should be taken under the guidance of a physician.)

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Written by Wu Hai Wu
Gastroenterology
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How large does a duodenal ulcer have to be to be considered severe?

There is no specific size to determine the severity of a duodenal ulcer. However, ulcers with a diameter greater than 1.5 cm are generally considered large. In such cases, strong acid-suppressing medications are needed for treatment, along with drugs to protect the gastric mucosa. Additionally, it is necessary to test for Helicobacter pylori infection. If the infection is positive, a bismuth-containing quadruple therapy should be used for two weeks to eradicate Helicobacter pylori. The choice of specific medications, as well as their dosages and administration, should be under the guidance of a doctor.