What are the symptoms of duodenal ulcers? Generally, the most obvious symptom of a duodenal ulcer is pain on an empty stomach, which often occurs at midnight or early morning, causing one to wake up from sleep in pain. This is a relatively clear symptom. When this symptom occurs, it is best to go to the hospital for a gastroscope examination as soon as possible. After a clear diagnosis, medication should be taken regularly and according to the treatment course for a cure. Generally, taking medications that inhibit gastric acid secretion and protect the intestinal mucosa, and medications for gastric mucosa, can be quite effective. It is also necessary to test for Helicobacter pylori, and if there is a concurrent infection, antibacterial treatment should be carried out.