Can iron deficiency anemia be cured?

Written by Li Fang Fang
Hematology
Updated on February 01, 2025
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Iron deficiency anemia is treatable, but it is essential to identify the cause of the iron deficiency. The treatment of iron deficiency anemia is divided into two main parts. The first part involves iron supplementation, which can be administered orally or intravenously, with intravenous supplementation generally being more effective and faster. The second part is crucial: identifying the cause of the iron deficiency. For example, common causes in women of childbearing age include heavy menstrual periods, while older patients often suffer from gastrointestinal tumors or ulcers, and in children, the common cause is usually nutritional deficiency. It is vital to treat the underlying cause.

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Written by He Li Fang
Hematology
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How long should iron supplements be taken for iron deficiency anemia?

First, it's important to understand that in treating iron deficiency anemia, addressing the underlying cause is the top priority. It's crucial to eliminate the causes of iron deficiency as much as possible. Solely supplementing with iron can only restore the blood picture, and neglecting the treatment of the primary illness will not lead to a thorough treatment of the anemia. Once the medication for anemia is stopped, it can easily relapse. So how long should iron supplements be taken for iron deficiency anemia? Generally, after patients start taking iron supplements, they can quickly feel an improvement in symptoms. The reticulocyte count tends to rise within three to four days after starting the supplements, reaching a peak around seven days. Hemoglobin shows a significant increase two weeks after starting the medication and can return to normal levels within one to two months. However, even after hemoglobin returns to normal, iron treatment should continue until the serum ferritin level has returned to 50 micrograms per liter before stopping the medication. If it's not possible to monitor serum ferritin, then iron supplements should be continued for three more months after hemoglobin has normalized, to replenish the body's iron stores. Therefore, the treatment of iron deficiency anemia with iron supplements generally lasts for three to six months.

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Written by He Li Fang
Hematology
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The causes of iron deficiency anemia

The causes of iron deficiency anemia primarily refer to the disruption of the normal dynamic balance between iron absorption and excretion, leading to the consumption of stored iron as well as an increased need for iron and insufficient iron intake, especially in cases of chronic blood loss, resulting in a long-term negative iron balance. The causes of iron deficiency can be divided into two main aspects: insufficient iron intake and excessive iron loss. In the first aspect, decreased iron intake includes dietary insufficiency, meaning inadequate food intake, and reduced absorption, which includes decreased absorption due to lack of stomach acid and reduced absorption following gastric surgery. Excessive iron loss includes the following eight aspects: 1) gastrointestinal bleeding, which includes bleeding caused by tumors, gastrointestinal ulcers, gastritis, as well as bleeding due to parasites and hookworm infections. It also includes bleeding caused by hemorrhoids in men and arteriovenous malformations; 2) excessive menstrual bleeding; 3) frequent blood donations; 4) multiple pregnancies in women; 5) chronic intravascular hemolysis causing hemoglobinuria; 6) hereditary hemorrhagic telangiectasia; 7) primary pulmonary hemosiderosis; and 8) coagulation disorders or the use of anticoagulants leading to iron deficiency. These eight categories all result from excessive loss of iron, causing iron deficiency which leads to iron deficiency anemia.

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Written by He Li Fang
Hematology
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Symptoms of iron deficiency anemia

The clinical manifestations of iron deficiency anemia consist of symptoms due to the anemia itself, specific manifestations of iron deficiency, and the underlying diseases causing the iron deficiency. The onset of anemia is often insidious, with some patients progressing very slowly. Initially, patients can adapt well to daily life and continue with their work, making it difficult to detect. It is usually not until the anemia becomes moderate to severe and symptoms become apparent that it is discovered. Common symptoms of anemia include dizziness, headaches, weakness, easy fatigue, palpitations, and shortness of breath after activity. Some patients might also experience a decline in memory and suffer from tinnitus and blurred vision. Some affected children may exhibit delayed growth and development or even abnormal behaviors, which can manifest as irritability, restlessness, inattention in class, and declining academic performance. A few patients may develop pica, a specific manifestation of iron deficiency anemia. Additionally, some patients might suffer from angular cheilitis, glossitis, and even atrophy of the tongue papillae. Severe cases can experience transient blindness and fainting, hence it is crucial to seek medical attention for iron deficiency anemia at the earliest.

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Written by He Li Fang
Hematology
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Which department should I go to for iron deficiency anemia?

The formed elements in the blood include red blood cells, white blood cells, and platelets, which play important roles in cellular metabolism, defense, and hemostasis, respectively. Among them, anemia falls under the category of red blood cell diseases. Iron-deficiency anemia refers to a condition where the body's iron stores are depleted, failing to meet the needs for normal red blood cell production. Before the production of red blood cells is restricted, the body's iron stores are already depleted, but anemia has not yet occurred, a condition we call iron deficiency, also known as the subclinical iron deficiency period clinically. Iron-deficiency anemia is a common red blood cell disease and falls under the category of hematology. Therefore, patients with iron-deficiency anemia should consult a specialist in hematology.

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Written by Hu Qi Feng
Pediatrics
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What are the symptoms of iron deficiency anemia in children?

Iron deficiency anemia can manifest as: 1. Gradual pallor of the skin and mucous membranes, especially noticeable on the lips, oral mucosa, and nail beds. Older children may experience dizziness, darkening before the eyes, and tinnitus. Additionally, anemia can lead to extramedullary hematopoiesis, and enlargement of the liver, spleen, and lymph nodes can occur. The younger the age and the longer the duration of the disease, the more severe the anemia and the more prominent the enlargement of the liver and spleen. 2. In terms of gastrointestinal tract: reduced appetite, pica, vomiting, diarrhea, and stomatitis may occur. 3. Nervous system manifestations include: restlessness or lethargy, lack of concentration, reduced memory, and intelligence often lower than peers of the same age. 4. Cardiovascular system: an increased heart rate may be observed, and in severe cases, cardiac enlargement and even heart failure can occur. 5. Immune system: Iron deficiency can affect hematopoietic function, often leading to reduced cell-mediated immune function and combined infections.