Iron deficiency anemia lacks iron.

Written by He Li Fang
Hematology
Updated on September 28, 2024
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Iron deficiency anemia is an anemia caused by the lack of stored iron in the body, affecting the synthesis of hemoglobin. It is characterized by a lack of stainable iron in the bone marrow, liver, spleen, and other organ tissues, as well as decreased serum iron concentration, transferrin saturation, and ferritin levels, typically presenting as microcytic hypochromic anemia. Thus, iron deficiency anemia refers to a deficiency of iron. Iron is an essential trace element in the human body, involved in cellular functions and metabolic processes. The body has a strict regulatory mechanism for iron metabolism to ensure that iron levels are always maintained at a normal level, referred to as iron homeostasis. Iron homeostasis relies crucially on the balance between intestinal iron absorption and the body's iron requirements. Once this balance is disrupted, problems in iron distribution, absorption, transport, and storage may occur, leading to iron deficiency anemia.

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Written by Hu Qi Feng
Pediatrics
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What are the symptoms of iron deficiency anemia in children?

Iron deficiency anemia can manifest as: 1. Gradual pallor of the skin and mucous membranes, especially noticeable on the lips, oral mucosa, and nail beds. Older children may experience dizziness, darkening before the eyes, and tinnitus. Additionally, anemia can lead to extramedullary hematopoiesis, and enlargement of the liver, spleen, and lymph nodes can occur. The younger the age and the longer the duration of the disease, the more severe the anemia and the more prominent the enlargement of the liver and spleen. 2. In terms of gastrointestinal tract: reduced appetite, pica, vomiting, diarrhea, and stomatitis may occur. 3. Nervous system manifestations include: restlessness or lethargy, lack of concentration, reduced memory, and intelligence often lower than peers of the same age. 4. Cardiovascular system: an increased heart rate may be observed, and in severe cases, cardiac enlargement and even heart failure can occur. 5. Immune system: Iron deficiency can affect hematopoietic function, often leading to reduced cell-mediated immune function and combined infections.

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Written by He Li Fang
Hematology
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Iron deficiency anemia clinical manifestations

Iron deficiency anemia presents in a variety of ways, including symptoms of anemia and iron deficiency. The main manifestation is tissue and organ hypoxia caused by iron deficiency, and severe iron deficiency anemia can lead to mucosal tissue changes and ectoderm nutritional disorders. Among the symptoms, we can find that in the early stages, the symptoms are relatively concealed and hard to detect. Patients with a slow progression can often adapt well in the early stages and are able to engage in daily work. Common symptoms of anemia include dizziness, headache, fatigue, and tiredness, along with palpitations and shortness of breath after activity, and even symptoms such as blurred vision and tinnitus. For patients with iron deficiency, specific symptoms include angular cheilitis, atrophy of the tongue papillae, glossitis, and severe iron deficiency patients may experience koilonychia, decreased appetite, nausea, and even constipation. Some patients, particularly children during their growth periods, may exhibit delayed growth and behavioral abnormalities, specifically being irritable and easily angered, having difficulty concentrating in class, and declining academic performance. A few patients may also develop pica, which is a special manifestation of iron deficiency anemia. In terms of physical signs, patients may exhibit pallor of the skin and mucous membranes, dry hair, and keratinization of the lips. Nails may be flat, lackluster, and prone to breakage, and a small number of patients may experience mild splenomegaly. These are the clinical manifestations of iron deficiency anemia.

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Written by He Li Fang
Hematology
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What are the symptoms of iron deficiency anemia?

Iron deficiency anemia is a type of anemia that exhibits common symptoms found in all anemia patients. It is characterized by a range of clinical symptoms caused by oxygen deficiency in tissue organs due to a lack of blood in the body. Common symptoms include dizziness, headaches, fatigue, shortness of breath and palpitations after activity, easy fatigability, difficulty concentrating, and decreased memory. Some patients may also experience blurred vision, ringing in the ears, and in severe cases, fainting, transient darkening of vision, and even arrhythmias. Because iron deficiency anemia is also accompanied by iron deficiency, it presents a range of clinical symptoms specific to iron deficiency, including pica, angular cheilitis, glossitis, unusual tongue conditions, decreased appetite, and even constipation among other symptoms.

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Written by He Li Fang
Hematology
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How is iron deficiency anemia diagnosed?

The diagnosis of iron deficiency anemia includes two aspects: one is to establish whether there is anemia caused by iron deficiency, and the other is to clarify the cause of the iron deficiency. First, we need to carefully inquire and analyze the medical history, combined with the patient's physical examination, which can provide a series of clues for diagnosing iron deficiency anemia. A definitive diagnosis also requires laboratory evidence. Clinically, we can divide iron deficiency and iron deficiency anemia into three stages: iron deficiency, iron-deficient erythropoiesis, and iron deficiency anemia. The following describes the diagnostic criteria for iron deficiency anemia specifically. Iron deficiency anemia is characterized by a significant reduction in hemoglobin in red blood cells, presenting as microcytic hypochromic anemia. Its diagnostic basis includes three aspects: first, conforming to the diagnosis of iron deficiency and iron-deficient erythropoiesis; second, having microcytic hypochromic anemia; and third, effective treatment with iron supplements. These three factors together can confirm the diagnosis of this disease.

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Written by He Li Fang
Hematology
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What is good to eat for iron deficiency anemia?

Iron deficiency anemia is a commonly seen type of nutritional anemia in clinical settings, with many causes. It can be caused by an insufficient intake of dietary iron needed to meet the body's demands. This insufficiency can also arise when the body's requirement for iron increases, or due to certain diseases, such as atrophic gastritis, lack of stomach acid, or the excessive use of antacids, which affect iron absorption. Increased bodily consumption due to conditions like diarrhea or hookworm infection can also lead to iron deficiency. For patients with iron deficiency anemia, it is generally recommended to improve the utilization of dietary iron. The first step is to modify dietary habits and lifestyle. For instance, it is suggested that vegetarians change their dietary patterns to include more iron-rich foods, such as animal liver, beef kidney, and chicken gizzards. Iron-rich vegetarian options include soy, black fungus, sesame paste, brown sugar, and dried fruits. Therefore, it is advisable for patients with iron deficiency anemia to increase their intake of these types of foods.