Vulvar cancer is a malignant tumor of the female reproductive system with a low incidence rate clinically. Many patients with vulvar cancer experience ulcerations in their lesions. Even when ulceration occurs in vulvar cancer lesions, it is not contagious to family members because vulvar cancer is a malignant tumor and does not possess contagiousness. The occurrence of infectious diseases necessarily requires three core elements: a source of infection, a transmission route, and a susceptible population. The formation of an infection without these three elements is impossible. When ulceration occurs in vulvar cancer lesions, it is due to the tumor lesion and is non-contagious; however, it is prone to concurrent infections, causing clinical symptoms such as fever, localized pain, and bleeding, which greatly afflict the patients. In cases of ulceration in vulvar cancer, besides controlling the infection and managing local symptoms, it is also necessary to provide aggressive anti-tumor treatment.