Rabies, once contracted, is incurable and leads to a 100% fatality rate.

The reason rabies is incurable primarily stems from the rabies virus invading the human body and proliferating extensively within the brain's nerves. This leads to the destruction of brain tissues and the exhaustion of brain functions, making it impossible to treat. Therefore, prevention of rabies is crucial. If there is exposure to the rabies virus, it is necessary to administer the rabies vaccine, and in some cases, it may also be necessary to administer rabies immunoglobulin concurrently.