For the treatment of kidney stones, larger kidney stones or multiple stones, stag-horn stones might consider surgical treatment. There are two types of surgery, the first is percutaneous nephrolithotomy, which involves inserting a nephroscope through a puncture in the kidney to break up and expel the stones from the body; the second type of surgery is ureteroscopy, which does not require an incision, by entering the kidney through the urethra and ureter, and then breaking up the stones and expelling them from the body.

Both surgical methods are performed under anesthesia, so the patient will not feel pain. However, pain after ureteroscopy is typically less than that after percutaneous nephrolithotomy, which requires absolute bed rest post-operation, while ureteroscopy does not.