What tests are involved in checking for uremia?

Written by Zhou Qi
Nephrology
Updated on February 13, 2025
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Uremia refers to the final stage of chronic renal failure, also known as end-stage kidney disease. Therefore, the first step in examining a patient with uremia is to check renal function. The patient's blood creatinine level must reach a certain level to diagnose uremia. Secondly, it is necessary to examine the urinary system through color Doppler ultrasound, and to conduct blood tests for routine blood indicators, electrolytes, parathyroid hormone, etc. The color Doppler ultrasound shows a reduction in kidney size, which provides evidence for the diagnosis of uremia. Patients with uremia often also suffer from various complications, including anemia, electrolyte disorders, hyperparathyroidism, and so on. Therefore, such patients also need to undergo examinations for routine blood parameters, electrolytes, and parathyroid hormone levels, among other indicators.

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Intensive Care Medicine Department
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What causes uremia?

Uremia is very common in clinical practice. It is mainly caused by abnormal kidney functions, leading to abnormalities in glomerular filtration, as well as in the reabsorption and secretion functions of the renal tubules, which results in a series of symptoms. Once uremia occurs, it can disrupt the internal environment of the body, cause electrolyte abnormalities, and even lead to life-threatening arrhythmias. Uremia is very dangerous in clinical practice and often requires regular hemodialysis treatment. Therefore, once uremia occurs, medical attention must be sought promptly.

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Nephrology
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Is uremia contagious?

Strictly speaking, uremia is not an independent disease and it is not contagious. Uremia refers to the state where numerous causes chronically damage the kidneys over a long period, eventually leading to the destruction of most kidney tissue, resulting in the kidneys' inability to excrete metabolic waste. There are many causes of uremia, including chronic nephritis, diabetes hypertension, systemic lupus erythematosus, urinary system stones, and even prostate hyperplasia, among others, which damage the kidneys and lead to this condition. Generally, these causes are not contagious as they do not involve bacteria, viruses, or fungi. However, if uremia is caused by infectious diseases, such as hepatitis B virus or HIV, these infectious diseases can be contagious, but uremia itself is not contagious.

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Symptoms of Uremia

Once diagnosed with uremia, patients exhibit numerous clinical symptoms, though these symptoms are not completely identical across different individuals. Typically, the primary symptoms of uremia include nausea, vomiting, loss of appetite, with these symptoms becoming more pronounced after eating. There might even be diarrhea, an increase in the frequency of bowel movements, and gastrointestinal bleeding. Additionally, patients show signs of edema, particularly around the eyelids and face, with very noticeable swelling in the lower limbs. Severe cases may also present with pleural effusion and ascites, accompanied by a reduction in urine output. Patients may also experience dizziness, headache, elevated blood pressure, and even exhibit pallor, anemia, itchy skin, bone pain, and intolerance to cold, among various other clinical symptoms.

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Is high creatinine uremia?

High creatinine levels do not necessarily indicate uremia, but during uremia, creatinine levels will certainly increase. Clinically, we consider creatinine levels above 707 as uremia. Once uremia is diagnosed, treatment mainly involves renal replacement therapy or transplantation. Renal replacement therapy mainly includes hemodialysis and peritoneal dialysis, each with its own advantages and disadvantages, and the choice should be based on the patient's individual condition. Renal transplantation is currently the best treatment option, which can be done through relatives or donations. After a kidney transplant, one can live and work like a normal person, but long-term oral immunosuppressive medication is required.

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Does uremia transmit to others?

Uremia is not contagious to others because it is not an infectious disease. Uremia is a severe renal failure, so patients with uremia can interact, communicate, live, work, and study with healthy people without the need for gastrointestinal or respiratory isolation. Normally, if a patient with uremia is stable, they can engage in sexual activities and the disease will not be transmitted through sexual contact. Uremia usually presents symptoms such as nausea, vomiting, edema, and increased blood pressure. Therefore, patients with uremia need to undergo dialysis treatment. They can choose either hemodialysis or peritoneal dialysis. Dialysis treatment can significantly improve the symptoms of uremia and enhance the quality of life of the patients.