Does teratoma require blood tests?

Written by Xu Xiao Ming

Obstetrics and Gynecology

Updated on October 31, 2024

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If a patient with a teratoma needs to undergo a blood test, the blood test may include routine blood work and blood biochemistry, as well as tumor marker tests such as CA125 and alpha-fetoprotein (AFP) to check for any abnormal increases. If surgery is required for the patient, there might be additional blood tests conducted, including lipid profile, thyroid function tests, and infection and immunity tests. All these require blood draws for the examination.

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Does a teratoma require surgery?

Ovarian teratomas are a type of germ cell tumor, requiring surgical treatment whether the teratoma is benign or malignant. Teratomas can be divided into mature teratomas and immature teratomas. Mature teratomas, also known as dermoid cysts, are considered benign tumors. Immature teratomas are malignant tumors, accounting for 1%-3% of ovarian teratomas. Mature teratomas are cystic with a single chamber filled with sebum and hair, and sometimes teeth and bone material can be found inside. Therefore, once a teratoma is identified, the choice of surgical method depends on the size of the tumor, and some biochemical tests are needed to determine the nature of the cystic tumor.

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How to Determine if a Teratoma is Benign

Teratomas in women are classified into benign and malignant categories. Benign teratomas typically have a complete capsule and grow very slowly. Some women find that the size of the teratoma does not change significantly during follow-up exams. Malignant teratomas, however, grow quickly and can present severe clinical symptoms, such as abdominal pain, bloating, and pelvic masses, with some women also experiencing fluid accumulation in the abdominal cavity. Furthermore, blood tests for gynecological tumor markers can also be used for differentiation. For example, in malignant tumors, markers such as CA-125, CA-199, and alpha-fetoprotein are elevated to varying degrees, particularly alpha-fetoprotein. During a CT scan, malignant teratomas may show unclear borders, potentially indicating invasion into the surrounding tissues. Additionally, after surgical removal of the tumor, pathological histological examination can be conducted for further differentiation. For instance, malignant teratomas tend to have a higher proportion of immature components.

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Written by Wang Jing Hua

Obstetrics and Gynecology

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Does a teratoma require immediate surgery?

Not all teratomas require immediate surgery. If a teratoma is found to be relatively small in size, many people can have it remain stable for a long time without significant changes, therefore periodic monitoring is possible. However, if a teratoma shows a rapid increase in size, or if it is already very large with the potential for torsion, or if there is a possibility of rupture or malignant transformation, or if the teratoma has endocrine activity, then immediate surgery may be necessary.

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Written by Shen Li Wen

Obstetrics and Gynecology

56sec

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Do teratomas grow quickly?

Ovarian teratomas are a relatively common type of ovarian tumor and belong to germ cell tumors. Depending on the benign or malignant nature of the teratoma, their differentiation and growth rates vary, meaning they grow at different speeds. For instance, benign teratomas, also known as mature teratomas, usually grow slowly. Many women may find that, upon having a check-up every six months or a year, the size of the teratoma remains the same with no significant changes. However, some women may have malignant teratomas, or their previously mature teratomas may become malignant. In such cases, the mass may suddenly increase in size over a short period, causing abdominal pain, and sometimes the mass can be felt in the abdomen.

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Obstetrics and Gynecology

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How is a teratoma diagnosed?

Teratomas are mostly diagnosed through symptoms, such as abdominal pain or bloating, and are identified with an ultrasound examination. Generally, these two tests are used. Additionally, blood tests may be conducted, but there are no very specific tumor markers that will be revealed. The primary means of diagnosis still rely on ultrasound and gynecological palpation. If a woman of childbearing age experiences unexplained abdominal pain, feels bloated, or notices occasional increases in abdomen size, it is recommended to undergo a gynecological ultrasound examination at a hospital.