Colon adenocarcinoma grade II, here the grade II generally refers to moderately differentiated, which is more severe than well-differentiated but relatively less severe than poorly differentiated or undifferentiated. However, the main criteria for assessing the severity of colon adenocarcinoma are not the degree of differentiation, but the depth of invasion, whether there is metastasis to nearby lymph nodes, and whether there is metastasis to distant organs. Based on the different situations mentioned above, different treatment methods should also be adopted. For patients with stage I colon cancer, surgical resection alone is sufficient. For patients with stage II and III colon cancer, postoperative adjuvant chemotherapy is needed in addition to surgical resection. For stage IV patients, systemic treatment is primarily conducted.