If you have trichomonal vaginitis and are menstruating, you cannot use topical treatments; instead, you must continue with oral medications. Take oral metronidazole tablets, and after your period, supplement with topical metronidazole suppositories. Combining these treatments is necessary to achieve a cure.

For trichomonal vaginitis, treatment must also be provided for the male partner, involving oral metronidazole tablets to prevent cross-infection. Trichomonas vaginitis is very prone to recurrence, often related to cross-infection between partners, and sometimes linked to unclean bed sheets, duvet covers, underwear, and panties. It is necessary to clean and disinfect these items thoroughly.