Melanoma is a highly malignant skin cancer, and clinically, some patients may experience pain when pressing on the lesion area. The reason for the pain is mainly due to the rapid growth of the melanoma, leading to compression of local tissues or the optic nerve and urgency, resulting in a painful sensation. This pain can exist even without pressing, and ulcerative lesions can occur in some affected areas, leading to symptoms such as pain, bleeding, and infection. In addition to pain upon local compression, patients with melanoma may also experience inflammatory changes such as redness, swelling, heat, and pain, causing some clinical symptoms of fever.