Pain in osteosarcoma patients is mostly caused by the cancer invading local bone tissue and other tissues, leading to pain, tenderness, and even sleeplessness. Therefore, the pain management follows a certain hierarchy, starting with non-steroidal anti-inflammatory drugs, followed by weak opioids, and finally strong opioids such as morphine. However, this only alleviates the pain and does not help with treatment. For early-stage osteosarcoma patients, pain management primarily involves surgery when necessary. For advanced-stage patients, it involves gradually increasing the dose of effective pain-relief medications to alleviate temporary pain. (Controlled drugs must be strictly used under the supervision of relevant physicians.)