Is genital herpes serology accurate?

Written by Luo Hong
Dermatology Department
Updated on September 03, 2024
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Serological testing for genital herpes in hospitals generally provides testing for type 1 and type 2 viruses, including IgM and IgG. Over 90% of genital herpes cases are primarily caused by type 2 virus, so the focus is typically on type 2 virus IgG and IgM. However, IgM represents an active infection, meaning a current infection stage. If IgM is negative and IgG is positive, it indicates a past infection. These results are generally accurate, but their timeliness is not as high as DNA's timeliness. Therefore, if possible, it is best to collect vesicle fluid on the first or second day of a herpes outbreak and use PCR to test the DNA for the most accurate results.

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Written by Liu Gang
Dermatology
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What are the transmission routes of genital herpes?

Genital herpes is caused by the herpes simplex virus type 2 infection, with the primary transmission route being sexual contact. However, some patients can also be infected through contact with contaminated clothing or through activities like bathing, swimming, or staying in hotels, although these methods have a relatively lower chance of transmission. Once infected with genital herpes, it generally persists for life and cannot be completely eradicated. Antiviral medications such as valacyclovir can be used during outbreaks, and topical acyclovir ointment can be applied locally. Regular exercise and consuming medications that enhance the immune system can help reduce the recurrence of this disease. If one frequently stays up late or consumes spicy and irritative food, the likelihood of recurrence increases. Moreover, this disease is highly contagious during outbreaks and can be transmitted to others through sexual contact.

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Written by Wang Zhi Guo
Dermatology
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Is genital herpes incurable forever?

Genital herpes is a common sexually transmitted disease characterized by its tendency to recur frequently. It often flares up when the body's resistance is low, during sleep deprivation, fatigue, or after drinking alcohol. Genital herpes is not incurable; it is generally treated with oral antiviral medications such as acyclovir, famciclovir, or valacyclovir. Topical applications, like acyclovir cream or penciclovir gel, can also be used. Recovery generally takes about a week. For those who suffer from frequent recurrences, oral immunomodulatory drugs such as thymopentin or pidotimod can be taken. Additionally, it’s important to exercise, avoid alcohol, and enhance the body's resistance to potentially achieve gradual recovery.

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Written by Luo Hong
Dermatology Department
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Can genital herpes be completely cured without recurrence?

Genital herpes is difficult to completely cure without recurrence because the virus from the previous herpes outbreak resides at the sacral nerve root. When resistance is low, typically during times such as drinking alcohol and staying up late, the herpes virus travels to the area served by the sacral nerve, such as the external genitals, buttocks, and perineal region, causing blisters. Therefore, it is very difficult to completely eliminate genital herpes so that it never recurs, but the likelihood of recurrence generally decreases significantly after five to six years. Therefore, what we need to do is mainly to enhance our immune function. We can use some medications to help boost immunity, and we should also try to drink less alcohol and get more sleep.

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Written by Zhai Yu Juan
Dermatology Department
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Can people with genital herpes eat seafood?

Genital herpes is a sexually transmitted disease caused by herpes simplex virus infection. The transmission routes mainly include sexual contact, close living contact, and mother-to-child transmission. Clinically, genital herpes primarily presents as clusters of erythema and blisters on the external genitals, with local burning and stabbing sensations. Initial outbreaks of genital herpes may include significant systemic symptoms such as fatigue and fever. After diagnosing genital herpes, antiviral medications like acyclovir are the first choice. In terms of diet, it is necessary to avoid spicy and irritating foods, pay attention to rest, and enhance immunity. Eating seafood is not a problem and does not affect the recovery and prognosis of genital herpes.

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Written by Luo Hong
Dermatology Department
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How is genital herpes tested?

Herpes viruses are generally divided into two types, type 1 and type 2 genital herpes, mainly caused by type 2 herpes virus. The best approach for type 2 herpes virus is to use blister fluid for PCR testing of DNA. If testing is not possible, you can also consider blood tests for herpes virus antibodies. If the IGM for type 2 herpes virus is positive, then consider it a current symptomatic infection. If the IGM is negative, but HCG is positive, then consider this herpes as a past infection.