Infantile colic usually occurs in infants within the first three months of birth, and typically manifests at night. Some children may experience brief episodes of colic, but for others, the episodes can be relatively prolonged, possibly lasting several hours.

When colic occurs, the infant may exhibit symptoms such as facial flushing, pale lips, abdominal distension, clenched fists, cold feet, and crying. Colic may subside after the infant passes gas or has a bowel movement. During a colic episode, parents should hold the child upright, allowing the child to lie on the adult's shoulder. The parent's hand should be hollow, gently patting the baby's back to help expel excess air from the stomach.