The initial symptoms of syphilis typically refer to the symptoms of primary and secondary syphilis. The symptoms of primary syphilis mainly include a chancre, usually a single superficial ulcer located at the genital area with a clear border, scant discharge, no pain, and no tenderness. Serological tests would show a positive result for Treponema pallidum. Some patients may also experience local lymph node enlargement. In secondary syphilis, patients often develop papules, macules, and vesicles on the skin, and symmetrical copper-red macules appear on the hands and feet. For the treatment of syphilis infection, penicillin is primarily chosen. If there is an allergy to penicillin, macrolide antibiotics can be used as an alternative. It is crucial to treat syphilis promptly after infection.