Syphilis belongs to a category of sexually transmitted diseases and is infected through sexual contact. The most common symptoms include a hard chancre at the genital area, presenting as a painless ulcerative lesion. Syphilis can be completely cured with proper treatment; however, even after complete recovery, the presence of Treponema pallidum will remain positive for life, which is irreversible. Most treated syphilis cases can return to normal titers or maintain at a normal level without pathogenicity or recurrence. During the treatment of syphilis, it is essential to maintain a proper diet and lifestyle habits, avoid soaking in public baths or swimming pools, ensure underwear worn is sun-disinfected, and abstain from sexual contact.