How long do you have to get a tetanus shot?

Written by Zhang Peng
General Surgery
Updated on March 21, 2025
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It is generally recommended to receive an injection as soon as possible after a trauma, ideally within 24 hours, because tetanus has a certain incubation period, with the shortest being able to cause disease within 24 hours. There is still value in receiving the injection after 24 hours; it can alleviate symptoms and play a preventive treatment role. For tetanus, it is usual to administer a tetanus shot, and most people can choose between tetanus antitoxin or tetanus immunoglobulin. The duration of these two drugs is not the same; tetanus antitoxin lasts about three days, while tetanus immunoglobulin can last up to three weeks. However, this is not an absolute conclusion. Beyond this time, if there are high-risk factors for reinfection, a repeat injection is needed. If a patient has previously been protected by an active immunization regimen, in most cases, no special preventive treatment is needed within three years of the last vaccination.

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Written by Li Chang Yue
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Can a tetanus shot be administered again?

If a tetanus shot is administered within 24 to 48 hours after injury, it can effectively prevent tetanus. However, if the tetanus shot is given a week or more after the injury, the effectiveness and relevance of the booster are generally not ideal. In such cases, tetanus immunoglobulin can be used for comprehensive antibody therapy to treat and prevent tetanus. Therefore, when the body sustains external injuries or certain infectious foci, it is crucial to promptly administer a tetanus shot intramuscularly, ideally within 24 hours, to effectively stimulate the body to produce the corresponding antibodies for protection.

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Does a tetanus shot stimulate the brain?

Tetanus shot, if administering tetanus toxoid, a skin test is required before injection. If the skin test is negative and there is no allergy, then the injection can proceed without stimulating the brain. A small proportion of patients undergoing anti-tetanus treatment might experience some uncomfortable reactions, commonly allergies, fever, and symptoms of vomiting. Generally, these can be alleviated with rest or symptomatic treatment. Only less than 1% of patients may experience seizures or coma, which are very rare reactions. If such reactions occur, it is urgent to go to a formal hospital for symptomatic and supportive treatment. For the vast majority of tetanus shots, if administered in a formal hospital and the patient has a negative skin test, or if given tetanus immunoglobulin, it does not stimulate the brain.

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Initial symptoms of tetanus

The bacterium that causes tetanus is Clostridium tetani, which is an anaerobic bacterium. If the wound is deep and enclosed in an environment lacking oxygen, it creates a suitable environment for the growth and reproduction of Clostridium tetani. Its incubation period is generally around one week. Early symptoms may include general fatigue, localized muscle tension, and uncontrollable spasms. The first muscles affected are usually the facial chewing muscles, and it can then progress to intense, spasmodic contractions of muscles throughout the body, and even cause fractures. Mild stimuli such as light, sound, or drinking water can trigger and worsen these symptoms, somewhat similar to rabies. However, a characteristic feature of tetanus is that the patient remains mentally clear. Most patients may die from respiratory spasms leading to asphyxiation, heart failure, or lung infections.

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Written by Li Jin Quan
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Is tetanus easy to get?

Tetanus is typically caused by the entry of Clostridium tetani into the body through broken skin or mucous membranes, producing toxins that lead to a specific infection. In daily life, Clostridium tetani is ubiquitous, present in places like moist soil, rusty iron, and some bamboo sticks. When an injury occurs, if the wound is deep, it should be promptly cleaned with hydrogen peroxide and saline solution. Then, it is best to go to a hospital to receive a tetanus vaccine within 24 hours. A wound that has been vaccinated against tetanus generally does not get infected. Therefore, when there is a wound, as long as the wound is timely cleaned, contaminants or foreign objects removed, and then a tetanus vaccine administered at a formal medical institution, tetanus is not so easy to contract.

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How long does the tetanus shot last?

The duration of the effectiveness of a tetanus shot depends on whether tetanus antitoxin or tetanus immunoglobulin is administered following a suspected tetanus infection. Both types are forms of artificial passive immunity, providing immediate specific immunity after injection, mainly for treatment or emergency prevention. The metabolism and immune duration of these two injections vary: generally, tetanus antitoxin lasts about seven days, while tetanus immunoglobulin can last up to three weeks. Therefore, the specific duration of the effectiveness of a tetanus shot must be determined based on the individual injection circumstances. For suspected tetanus infections, it is generally advised to administer the injection as soon as possible. It's not that the injection will be ineffective if administered after a certain time, but rather that effective prevention before the onset of the disease can still be beneficial.