When experiencing delayed menstruation and symptoms of breast tenderness, the first consideration should be related to pregnancy. As long as there has been sexual activity, whether contraception was used or not, a pregnancy test should be conducted. However, not all cases of ceased menstruation and breast tenderness are related to pregnancy; some people may experience these symptoms before their period, which can only be differentiated by medical examination.

If menstruation has stopped for two weeks and pregnancy is still ruled out upon re-examination, then intervention should be considered. An ultrasound should be performed. For some, symptoms of breast tenderness may be related to staying up late, excessive stress, the tightness of bras, or breast hyperplasia, among other factors.