Whether taking anti-inflammatory drugs is needed for enlarged turbinates depends first on identifying the cause of the enlargement.

If the enlargement of the turbinates is caused by bacterial infection, it is appropriate to take anti-inflammatory medication such as antibiotics. However, if it is caused by allergies, antibiotics will be ineffective.

Generally, there are two reasons for enlarged turbinates. The first is due to symptoms caused by acute inflammatory infections, commonly seen in clinical cases of acute rhinitis or acute sinusitis. Clinically, these are most often caused by infections from hemolytic streptococci or Staphylococcus aureus, resulting in congested, swollen, and hypertrophic mucous membranes of the turbinates. Antibiotics such as penicillin or cephalosporin can be effective in treatment.

However, antibiotics are ineffective for allergic rhinitis. Allergic rhinitis occurs when the immune and resistance levels are low, and the nasal cavity comes into contact with related allergens. Patients will also experience enlarged turbinates, along with symptoms like sneezing and runny nose. Treatment should focus on symptomatic allergy treatment to shrink the turbinates and alleviate nasal congestion.