In the late stages of cirrhosis, when the condition has progressed to liver failure, it becomes very difficult to manage. At this stage, due to liver failure, the first issue to arise is abnormal coagulation function, such as easy bleeding in patients. This will lead to severe hypoalbuminemia, causing swelling throughout the body. Additionally, bilirubin levels are very high, leading to various metabolic diseases, such as metabolic encephalopathy, which affects other organs as well.

In the late stages of cirrhosis, there is also a large amount of ascites. At this time, portal hypertension is common, leading to complications such as gastric and esophageal varices rupture, bleeding, and hepatic encephalopathy, making the condition very difficult to control.

If the cirrhosis is a benign lesion, at this time, adjusting liver function through methods such as artificial livers or plasma exchange can improve the condition to a manageable extent. It is critical to act quickly to perform a liver transplant, as there are no other effective treatments besides transplant, and the condition is very difficult to control.