Effects of gestational diabetes on the fetus

Written by Chen Xie
Endocrinology
Updated on September 17, 2024
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The impact of gestational diabetes on the fetus mainly manifests in early stages as spontaneous miscarriage, fetal malformations, and abnormal fetal development. As the fetus grows, the high maternal blood sugar levels can lead to a large fetus, which increases the risk of birth injuries during delivery. Due to the high insulin levels in the mother, the fetus may have hyperinsulinemia, which can cause recurrent hypoglycemia at birth. Additionally, the development and maturation of the fetal lungs are delayed, making the newborn more susceptible to respiratory distress syndrome. Furthermore, gestational diabetes also increases the risk of preterm birth.

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Written by Luo Han Ying
Endocrinology
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What should I do about gestational diabetes?

As prenatal checkups are becoming increasingly popular, many expectant mothers undergo a glucose tolerance test between the 24th and 28th week of pregnancy to diagnose gestational diabetes. More and more expectant mothers are finding their blood sugar levels exceeding the diagnostic thresholds and are being diagnosed with gestational diabetes. Most of the time, gestational diabetes in expectant mothers is caused by reduced physical activity and overeating during pregnancy. For such expectant mothers, we can advise them to control their weight, strictly manage their diet, and increase their physical activity to maintain proper blood sugar levels. In fact, only a small portion of pregnant women diagnosed with gestational diabetes require insulin injections to control their blood sugar.

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Written by Liang Yin
Endocrinology
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How is gestational diabetes treated?

The treatment of gestational diabetes includes dietary therapy, exercise therapy, and insulin therapy. For dietary therapy, we mainly control the total calorie intake and supplement with elements such as calcium, iron, folic acid, and various vitamins; in exercise therapy, we aim to control the speed of weight gain, improve the peripheral tissues' utilization of glucose, and improve the lipid profile. For patients whose blood glucose levels do not meet the standards after two weeks of diet and exercise therapy, we initiate insulin therapy. The goal of insulin therapy is to control fasting blood glucose below 5.3 and postprandial blood glucose below 6.7. The methods of insulin therapy include twice daily injections, multiple daily injections, or the use of an insulin pump.

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Written by Luo Han Ying
Endocrinology
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Does gestational diabetes require early delivery?

Patients with gestational diabetes primarily have higher blood sugar levels compared to normal pregnant women. For such individuals, strict blood sugar control is generally required. Poor control of blood sugar can significantly impact the baby and pose dangers during childbirth. However, for those patients with well-controlled gestational diabetes, it is possible to carry the pregnancy to full term without the need for early delivery. Early delivery, leading to a premature birth, can have a greater detrimental effect on the infant than the effects caused by high blood sugar. Therefore, patients with gestational diabetes do not need to deliver early. They can manage their condition through strict dietary control, including fetal monitoring and close monitoring of the baby’s vital signs, considering delivery only after reaching full term.

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Written by Chen Xie
Endocrinology
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Gestational diabetes blood sugar standards

The diagnostic criteria for gestational diabetes involve a pregnant woman undergoing a 75-gram glucose test at any time during pregnancy to measure fasting blood glucose, blood glucose one hour after consuming glucose, and blood glucose two hours after consuming glucose. The thresholds are: fasting blood glucose equal to or greater than 5.1 mmol/L, blood glucose one hour after glucose intake equal to or greater than 10.0 mmol/L, and blood glucose two hours after glucose intake equal to or greater than 8.5 mmol/L. Diagnosis of gestational diabetes can be made if blood glucose levels exceed these standards at any of the three time points. In China, pregnant women typically undergo the 75-gram glucose test between the 24th to 28th week of pregnancy. Women at high risk for gestational diabetes are advised to undergo the 75-gram glucose test early.

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Written by Chen Li Ping
Endocrinology
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Does gestational diabetes cause itching in the vulva?

During gestational diabetes, white blood cells have various functional defects, reduced chemotaxis, phagocytic action, and bactericidal activity. This can easily lead to infections during pregnancy or childbirth, and even develop into sepsis, often caused by bacteria or fungi. Therefore, when blood sugar is not controlled in gestational diabetes, there may be symptoms like vulvar itching, or even infections of the urinary or reproductive systems. If the infection is not further treated, it may cause preterm birth, or even septic shock. Therefore, in gestational diabetes, it is crucial to actively control blood sugar and prevent infections.