Normal uterine fibroids do not cause an increase in CRP. CRP is an indicator of systemic inflammatory response. Only when a patient experiences infection, rupture, or acute systemic inflammatory reactions will it cause a rise in tumor markers. Uterine fibroids often do not exhibit these symptoms; therefore, most cases will not show an increase in CRP. However, in some patients, infection or rupture, and even malignancy, can lead to an increase in these indicators. Patients should undergo relevant imaging studies to assess the size and location of the uterine fibroids, as well as the presence of uterine bleeding.