Malignant symptoms of uterine fibroids

Written by Li Shun Hua
Obstetrics and Gynecology
Updated on May 18, 2025
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If uterine fibroids become malignant, they can increase significantly in size in a short period. Patients may feel a lump in the abdomen, and this lump grows rapidly and is tender to pressure. Additionally, there may be symptoms such as heavy menstrual bleeding, prolonged menstrual periods, and irregular vaginal bleeding, as well as pain in the lower abdomen. Other symptoms include compression effects such as frequent urination, urgency to urinate, and difficulty defecating. Therefore, it is necessary to re-examine uterine fibroids every six months to a year. If uterine fibroids are found to be growing rapidly, timely surgical treatment should be conducted to prevent malignant transformation.

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Written by Liu Jian Wei
Obstetrics and Gynecology
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Reasons for the sudden enlargement of uterine fibroids

Uterine fibroids generally grow slowly. In clinical practice, if there is a sudden increase in the size of uterine fibroids in a short period, it is recommended that the patient immediately seek medical attention at a local hospital to ascertain the cause. Commonly observed reasons for an increase in the size of uterine fibroids include: firstly, if the uterine fibroids are tending towards malignancy, they can increase in size rapidly. Additionally, during pregnancy, under the influence of high levels of hormones in the body, pregnant women may also experience a sudden increase in the size of uterine fibroids, accompanied by red degeneration.

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Written by Wang Kun
Surgical Oncology
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Does uterine fibroids cause high CRP?

Normal uterine fibroids do not cause an increase in CRP. CRP is an indicator of systemic inflammatory response. Only when a patient experiences infection, rupture, or acute systemic inflammatory reactions will it cause a rise in tumor markers. Uterine fibroids often do not exhibit these symptoms; therefore, most cases will not show an increase in CRP. However, in some patients, infection or rupture, and even malignancy, can lead to an increase in these indicators. Patients should undergo relevant imaging studies to assess the size and location of the uterine fibroids, as well as the presence of uterine bleeding.

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Written by Wang Jing Hua
Obstetrics and Gynecology
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Do uterine fibroids have a genetic component?

Uterine fibroids indeed have a certain hereditary quality, similar to some other tumors or diseases, with a definite familial genetic component. However, the condition of uterine fibroids varies from person to person and is also related to acquired factors such as estrogen levels. The majority of uterine fibroids are simply carried, with the incidence in the population reaching over 20%. Many people with uterine fibroids do not need to worry about them, and no surgery is required, as regular check-ups are sufficient. After menopause, some fibroids may shrink and gradually disappear on their own. Some uterine fibroids during the reproductive years will ultimately require surgery, and there is also a small chance of needing surgery after menopause.

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Written by Sun Shan Shan
Obstetrics and Gynecology
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Are uterine fibroids likely to recur?

Firstly, uterine fibroids are prone to recurrence in women of childbearing age. The main cause of uterine fibroids is usually an excessively high level of estrogen in the body, along with an uneven distribution of estrogen levels, which leads to the development of fibroids. Once a woman is of childbearing age and has regular menstrual cycles, uterine fibroids tend to recur. If uterine fibroids occur, it is necessary to go to the hospital for a color ultrasound examination to check the location of the fibroids. Uterine fibroids can be categorized into cervical fibroids and corpus fibroids. If cervical fibroids are found, timely surgical treatment is required because they become more difficult to treat and more prone to bleeding as they grow larger. Additionally, for corpus fibroids, it depends on whether they are intramural or submucosal. If submucosal uterine fibroids are present, they also require timely surgical intervention due to the risk of prolonged bleeding and potential anemia.

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How to treat uterine fibroids?

Uterine fibroids are the most common benign tumors of the female reproductive organs, consisting of smooth muscle and connective tissue, mostly seen in women aged 30-50. Uterine fibroids can be classified into fibroids of the uterine body and cervical fibroids. Depending on their location, the treatments differ. Fibroids of the uterine body are further divided into intramural fibroids, subserosal fibroids, and submucosal fibroids. In cases of submucosal fibroids, prompt symptomatic treatment is necessary once detected, as these fibroids grow towards the uterine cavity and protrude into it, covered only by the endometrium on the surface. Hence, timely surgical intervention and regular physical examinations are crucial for submucosal fibroids.