Pleurisy can cause anterior chest pain. It is a very common clinical disease, mostly caused by bacterial invasion of the pleura resulting in inflammatory lesions, with Mycobacterium tuberculosis being the most common pathogen. Due to inflammatory exudation, some patients may also experience varying degrees of pleural effusion. The clinical symptoms presented by patients mainly include fever, cough, shortness of breath, chest tightness, and chest pain. In severe cases, different levels of breathing difficulties and other clinical symptoms may occur. Therefore, it is very common for patients with pleurisy to experience anterior chest pain.