If a patient has a history of pericardial effusion, this condition may present with eyelid edema. Because cardiac tamponade can cause the patient to experience sodium and water retention, this retention can manifest as eyelid edema, as well as edema in both lower limbs. In cases where the volume of pericardial effusion is substantial, surgical treatment, such as aspiration for fluid extraction, may sometimes be necessary. For minor and smaller volumes of pericardial effusion, the effusion can be absorbed on its own, with symptomatic treatment being the main approach. Eyelid edema can occur with pericardial effusion, and active treatment should be pursued. Using medications to improve symptoms can provide relief.