Is bladder cancer hereditary?

Written by Wang Jian
Urology
Updated on September 28, 2024
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Bladder cancer is the most common malignant tumor in urology, occurring on the mucosa of the bladder and is also one of the top ten common tumors globally. The etiology of bladder cancer is complex, involving both intrinsic genetic factors and external environmental factors, which gives bladder cancer a hereditary tendency. Notable among the major risk factors are smoking and occupational exposure to aromatic amines, with 30% to 50% of bladder cancers caused by smoking. The incidence of bladder cancer significantly increases with the duration of smoking. The initial clinical manifestation of bladder cancer is usually hematuria, typically painless and intermittent gross hematuria. The presence of blood in urine should prompt further diagnostic testing to rule out malignant tumors in the bladder.

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Written by Guan Hai Fang
Urology
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How is bladder cancer treated?

How is bladder cancer treated? Currently, the primary treatment option for bladder cancer is surgery, which can include procedures like transurethral tumor resection, bladder tumor resection, urethral tumor resection through the bladder, and cystectomy, among others. The specific surgical approach is selected based on factors such as the location and size of the bladder cancer. Besides surgical removal of the bladder, other treatment methods such as radiation therapy, chemotherapy, new technology treatments, and traditional Chinese medicine are also available as adjunct therapies. The formulation of a treatment plan should comprehensively consider factors such as the location, size, and stage of the bladder cancer.

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Written by Liu Liang
Oncology
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Does bladder cancer require the removal of the bladder?

Whether or not to remove the entire bladder in cases of bladder cancer depends on whether the tumor has invaded the base layer and whether there is distant metastasis. For non-muscle invasive bladder cancer, where the muscle layer is not invaded and there is no distant metastasis, typically found in stage 0 and stage 1 bladder cancer patients, there is no need for complete removal of the bladder. The standard treatment in such cases generally involves transurethral resection of the bladder tumor. If the tumor has invaded the base layer but there is no distant metastasis, termed muscle-invasive bladder cancer, patients in this category require radical cystectomy, which involves the removal of the entire bladder. If there is distant metastasis, termed metastatic bladder cancer, surgical treatment is not pursued; instead, palliative chemotherapy is the primary approach.

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Written by Liu Liang
Oncology
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What medicine is infused into the bladder for bladder cancer?

Postoperative intravesical chemotherapy infusion is very common in the treatment of bladder cancer. Common drugs used for infusion chemotherapy include mitomycin and anthracyclines such as epirubicin or pirarubicin. Gemcitabine is also frequently used for this purpose. The related side effects generally include irritation symptoms of the bladder, although some patients may experience relatively mild side effects.

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Written by Wang Jian
Urology
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Is bladder cancer scary?

Bladder cancer is the most common malignant tumor in urological surgery, primarily occurring in the bladder mucosa. Its symptoms include painless, intermittent gross hematuria, with nearly 100% of patients experiencing blood in the urine. The presence of hematuria should highly raise the suspicion of bladder cancer, and the examinations mainly include routine urinalysis and an ultrasound of the urinary system. Bladder cancer is not to be feared if it is detected and treated early. The surgery can be relatively simple, and minimally invasive treatment through the urethra, such as plasma electrosection or laser excision, is possible. Since bladder cancer can recur, postoperative management should include bladder perfusion therapy and regular cystoscopy re-examinations. Thus, bladder cancer is not to be feared, as early detection and treatment can lead to a cure.

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Written by Chen Feng
Urology
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Can urine odor be a sign of bladder cancer?

Urine with an unusual odor may be caused by bladder cancer, but the presence of an odor alone cannot be used to diagnose bladder cancer. Clinically, urine with an odor is commonly associated with urinary tract infections, as patients with such infections tend to have a higher amount of inflammatory secretions in their urine. Additionally, patients with urinary tract infections may lose some body water through sweating, leading to more concentrated urine, which can increase the odor. Bladder cancer patients are more susceptible to urinary tract infections, so they may also experience odorous urine. Clinically, bladder cancer is diagnosed through a combination of the patient's symptoms and supportive diagnostic tests. In the early stages of the disease, bladder cancer typically presents as painless hematuria (blood in the urine) that persists for an extended period. A routine urinalysis can be performed to check for elevated red blood cells in the urine. If bladder cancer is suspected, a cystoscopy can be conducted to identify any masses in the bladder and take biopsy samples for pathological examination. The presence of tumor cells in these samples generally confirms a diagnosis of bladder cancer.