Methods of Tuberculosis Examination

Written by Wang Xiang Yu
Pulmonology
Updated on June 23, 2025
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The examination methods for tuberculosis are now quite numerous, but achieving a diagnosis is still relatively difficult. The most commonly used method is still chest imaging, mainly X-rays and CT scans. Additionally, there are bacteriological examinations, such as examining sputum or other samples like pleural effusion under a microscope after staining. Culturing Mycobacterium tuberculosis, with sputum being the most commonly used sample, followed by pleural effusions and bronchoalveolar lavage fluid, is also common. A newer method is molecular biology examination, also known as Mycobacterium tuberculosis DNA nucleic acid testing. Then there is the pathological examination of tuberculosis, commonly referred to as biopsy, which involves taking a small piece of tissue from the lesion for observation. Moreover, some new immunological tests have emerged, including the traditional tuberculin skin test, still relevant today, and the gamma interferon release assays, along with traditional tests like Mycobacterium tuberculosis antibody tests. Additionally, some patients might require more invasive examinations, such as bronchoscopy, which allows direct observation of the trachea and bronchi and can be used for brush tests or biopsies at the lesion site.

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Written by Han Shun Li
Pulmonology
1min 3sec home-news-image

How is tuberculosis treated?

The treatment of tuberculosis generally involves two aspects: etiological treatment and symptomatic management. Etiological treatment targets the tuberculosis bacteria with medication. Modern anti-tuberculosis chemotherapy regimens are quite mature, employing strategies such as early and combined use, appropriate dosing, regular administration, and full-course treatment, which result in a very high cure rate. Additionally, there is symptomatic management, for example, cough suppressants for patients with a cough, expectorants for those with excessive sputum, antipyretics if there is fever depending on the situation, and hemostatic drugs for patients coughing up blood, among others. The treatment of pulmonary tuberculosis is comprehensive and must be conducted under the guidance of a physician. It is crucial not to interrupt treatment casually to avoid affecting the effectiveness of the therapy, increasing the recurrence rate, and the emergence of drug resistance.

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Written by Wang Xiang Yu
Pulmonology
1min 51sec home-news-image

How to test for tuberculosis

To examine pulmonary tuberculosis, it is essential to understand that it pertains to tuberculosis changes in the lung tissue, airways, bronchi, and pleura. The pathogen causing tuberculosis is Mycobacterium tuberculosis, also known as the tubercle bacillus. There are multiple tests available for people with pulmonary tuberculosis, as the disease can vary based on location and type. Therefore, such patients generally require numerous tests. The most commonly used are imaging studies for the chest, including X-rays and CT scans. In imaging studies, most patients will show some lesions, but there are instances where tuberculosis in the airways and bronchi might not be clearly visible on CT or X-rays, necessitating more invasive tests like bronchoscopy. Additionally, bacteriological examinations, such as sputum smear and pleural fluid smear, as well as culture for Mycobacterium tuberculosis, are typically conducted for patients. Nowadays, hospitals equipped with the necessary facilities conduct molecular biological tests, namely nucleic acid testing for Mycobacterium tuberculosis DNA. Furthermore, some patients with complex conditions may require a histopathological biopsy, commonly referred to as tissue sampling, at the site of the lesion to observe under a microscope for characteristic changes indicative of tuberculosis. There are also immunological tests that assist in diagnosing tuberculosis, such as the gamma interferon release assay (commonly known as the T-SPOT), tuberculin skin test, and traditional antibody tests against Mycobacterium tuberculosis.

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Written by Wang Xiang Yu
Pulmonology
1min 29sec home-news-image

Methods of Tuberculosis Examination

The examination methods for tuberculosis are now quite numerous, but achieving a diagnosis is still relatively difficult. The most commonly used method is still chest imaging, mainly X-rays and CT scans. Additionally, there are bacteriological examinations, such as examining sputum or other samples like pleural effusion under a microscope after staining. Culturing Mycobacterium tuberculosis, with sputum being the most commonly used sample, followed by pleural effusions and bronchoalveolar lavage fluid, is also common. A newer method is molecular biology examination, also known as Mycobacterium tuberculosis DNA nucleic acid testing. Then there is the pathological examination of tuberculosis, commonly referred to as biopsy, which involves taking a small piece of tissue from the lesion for observation. Moreover, some new immunological tests have emerged, including the traditional tuberculin skin test, still relevant today, and the gamma interferon release assays, along with traditional tests like Mycobacterium tuberculosis antibody tests. Additionally, some patients might require more invasive examinations, such as bronchoscopy, which allows direct observation of the trachea and bronchi and can be used for brush tests or biopsies at the lesion site.

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Written by Xiong Hong Hai
Infectious Disease
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Can people with tuberculosis drink alcohol?

Patients with tuberculosis should not drink alcohol. They need to rest well, enhance their nutrition, and abstain from smoking and drinking. Systematic and standardized anti-tuberculosis treatment is necessary. With standardized anti-tuberculosis treatment, the tuberculosis bacteria can be effectively suppressed, symptoms can be controlled, and the patient’s weight can increase. It is crucial to abstain from smoking and drinking during treatment, as drinking can lead to poor treatment outcomes and even the development of drug-resistant tuberculosis. With timely and standardized medication and comprehensive treatment, most patients can generally be cured within a six-month course of anti-tuberculosis treatment.

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Written by Wang Chun Mei
Pulmonology
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Does tuberculosis cause headaches in its initial stage?

Tuberculosis is a highly contagious respiratory disease caused by the infection of Mycobacterium tuberculosis in the lungs, generally transmitted through respiratory droplets or direct contact. When infected with tuberculosis, symptoms that often appear include low-grade fever in the afternoons, coughing, expectoration, hemoptysis, chest pain, chest tightness, and shortness of breath. Some may experience weight loss, fatigue, and night sweats. Therefore, when patients with pulmonary tuberculosis exhibit an afternoon low-grade fever, it often leads to the occurrence of headaches. Therefore, it is very common for patients in the early stages of pulmonary tuberculosis to exhibit various symptoms, primarily due to the rise in body temperature.