Hypokalemia is not directly related to smoking. However, once hypokalemia occurs, there is definitely an underlying disease. In the case that the primary disease is not controlled, it is advisable to avoid smoking. Potassium is an essential electrolyte for life, and its physiological functions mainly include maintaining cellular metabolism, regulating osmotic pressure, acid-base balance, and maintaining cell stress functions. Once hypokalemia occurs, active treatment should be implemented, primarily addressing the primary disease, symptomatic treatment with potassium supplementation, and avoiding the occurrence of hyperkalemia. The principle of potassium supplementation is that for mild hypokalemia without clinical manifestations, oral potassium should be given; in cases of severe hypokalemia, intravenous potassium supplementation should be administered immediately. Intravenous potassium should ideally not use peripheral veins but establish a central vein, and the speed of potassium supplementation and the monitoring of potassium levels should be controlled.