Gastric ulcer and duodenal ulcer

Written by Jiang Guo Ming
Gastroenterology
Updated on September 04, 2024
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Gastric ulcers and duodenal bulb ulcers both belong to upper gastrointestinal ulcers. Their symptoms slightly differ; gastric ulcers typically manifest as postprandial pain in the upper abdomen, whereas duodenal bulb ulcers present as hunger pains in the upper abdomen, sometimes accompanied by nocturnal pain. Both types generally exhibit symptoms such as acid reflux and heartburn. The predominant cause for these is infection by Helicobacter pylori, detectable through tests such as the carbon-13 or carbon-14 breath test. If an infection is present, antimicrobial treatment can typically lead to a complete recovery of the ulcers. If there is no Helicobacter pylori infection, the initial approach should still focus on symptomatic treatment. Additionally, adopting good dietary and living habits can facilitate regular gastroscopic follow-ups.

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Written by Li Xue Qing
Gastroenterology
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What is a stomach ulcer?

Peptic ulcer is caused by long-term Helicobacter pylori infection and the consumption of stomach-irritating medications such as corticosteroids, aspirin, and long-term use of non-steroidal anti-inflammatory drugs, as well as irregular intake of spicy, stimulating, and cold foods, coupled with long-term emergency mental factors, leading to postprandial pain. The main symptoms are periodic rhythmic upper abdominal pain, which may be accompanied by nausea, vomiting, and acid reflux. Diagnosis can be made by performing a gastroscopy. Treatment mainly involves the eradication of Helicobacter pylori and protective stomach treatments among other symptomatic treatments. Complications may include upper gastrointestinal bleeding, perforation, pyloric obstruction, and malignant transformation. Dietary recommendations include avoiding smoking, alcohol, strong tea, coffee, indigestible foods, and some stimulating condiments.

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Written by Jiang Guo Ming
Gastroenterology
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How to treat bleeding from gastric ulcers?

If it is a mild gastric ulcer bleeding, it may only manifest as black stool without any obvious specific discomfort symptoms and stable vital signs. This condition can be managed by controlling the diet and appropriately taking or intravenously using proton pump inhibitors such as omeprazole, lansoprazole, etc., which often can be curative. If the bleeding is considerable, presenting symptoms like vomiting coffee-colored or dark red liquid, fainting, profuse sweating, blood pressure drop, etc., this condition requires timely hospital treatment. Medication primarily includes proton pump inhibitors combined with hemostatic drugs, nutritional support, prevention of complications, etc. If the medical treatment is ineffective, endoscopic hemostasis might be needed, and further more, surgical intervention may be considered.

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Written by Jiang Guo Ming
Gastroenterology
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What medicine to take for gastric ulcer?

The stomach ulcers referred to here are generally benign gastric ulcers. The treatment plan should be determined based on whether there is a Helicobacter pylori infection. If there is no Helicobacter pylori infection, it is first important to develop good dietary and living habits, and then treat the symptoms, such as suppressing stomach acid, protecting the gastric mucosa, and increasing gastric motility. If there is a Helicobacter pylori infection, antibacterial treatment is needed. Typically, a triple or quadruple antibiotic therapy is used; a proton pump inhibitor plus two antibiotics constitute the triple therapy, and adding a bismuth agent constitutes the quadruple therapy. A course of treatment lasts for two weeks, which generally can eradicate the bacteria for a definitive cure. (Medications should be used under the guidance of a clinical doctor, according to specific conditions.)

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Written by Ren Zheng Xin
Gastroenterology
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Does gastric ulcer require hospitalization?

Whether a stomach ulcer requires hospitalization depends on the condition. For minor ulcers, if the pain is mild and there are no significant symptoms of vomiting or nausea, treatment can be managed with medication, such as drugs that inhibit stomach acid secretion and protect the gastric mucosa. It is also important to regulate diet, eat soft foods, avoid cold, spicy foods, and alcohol, as symptoms can gradually ease. If the ulcer is larger and exhibits perforation or bleeding, hospital treatment is necessary, usually involving a significant portion of the stomach being surgically removed to completely cure the ulcer. (Medication should be taken under the guidance of a doctor.)

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Written by Li Xue Qing
Gastroenterology
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How should gastric ulcers be treated?

The treatment of gastric ulcers is divided into general treatment and medication treatment. General treatment mainly requires patients to avoid spicy, irritating, and cold foods, maintain a calm mindset, have regular meals, and avoid the use of some drugs that can damage the stomach, such as non-steroidal anti-inflammatory drugs. Medication treatment can be administered through gastric protection, which includes drugs that neutralize stomach acid, such as magnesium aluminum carbonate chewable tablets. Drugs that suppress stomach acid include proton pump inhibitors and H2 receptor blockers. Medications that protect the gastric mucosa include sucralfate, bismuth preparations, etc. Additionally, there is targeted eradication treatment for Helicobacter pylori, which clinically includes triple and quadruple therapies. Triple therapy refers to a proton pump inhibitor or a bismuth agent combined with two antibiotics. Quadruple therapy consists of a proton pump inhibitor added to a bismuth agent and two antibiotics, which could include amoxicillin, clarithromycin, levofloxacin, furazolidone, metronidazole, tetracycline, etc. Treatment generally lasts seven to ten days, and the overall treatment for gastric ulcers is typically around one month. (Medications should be used under the guidance of a doctor based on the specific situation.)