How is Parkinson's disease diagnosed?

Written by Zhang Hui
Neurology
Updated on May 16, 2025
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For the diagnosis of Parkinson's disease, the patient's medical history and symptoms are very important, and physical examinations are also an important reference for diagnosis. The physical examination generally involves checking the patient's muscle tone and looking for signs of bradykinesia. In terms of auxiliary examinations, on one hand, it is necessary to perform ceruloplasmin tests, which primarily aim to exclude hepatolenticular degeneration. Brain MRI scans are also conducted to exclude other causes of secondary Parkinson’s disease, such as normal pressure hydrocephalus and cerebrovascular diseases. Additionally, these patients need to undergo olfactory tests and some PET-CT scans to clarify the diagnosis.

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Written by Zhang Hui
Neurology
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What medicine is used for Parkinson's disease?

Parkinson's disease is a relatively common neurological disorder, with a higher incidence in middle-aged and elderly people. Currently, there is no specific cure for the disease, but there are many medications that can significantly improve the symptoms of Parkinson's disease. The commonly used medications mainly include: The first major category is Levodopa preparations. This type of medication has good efficacy but can cause some adverse drug reactions and may provoke the occurrence of motor complications. It should be taken under the advice of a doctor. The second major category of drugs is dopamine receptor agonists. These drugs also have relatively good effects and can improve the motor symptoms of patients, though they may be a bit expensive. Third, anticholinergic drugs. They can significantly improve the patients' normal symptoms, but should not be taken by patients with cognitive impairments. Additionally, there are monoamine oxidase inhibitors and COMT inhibitors that can also be used.

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What tests are done for Parkinson's disease?

Parkinson's disease is a degenerative disease of the nervous system. Many patients report that numerous examinations did not identify a clear cause of the disease, which is typical of this condition due to the lack of very effective diagnostic methods. Patients' symptoms gradually worsen, manifesting as motor slowness, limb tremors, muscle rigidity, and other clinical signs. There are also symptoms such as constipation and dizziness. Generally, the following examinations are recommended for Parkinson's disease: First, complete a cranial MRI scan. The primary purpose of a cranial MRI is to exclude other causes of Parkinson's-like symptoms, such as cerebral thrombosis, brain tumors, or inflammation. Second, perform olfactory tests, as some patients may experience a significant reduction in their sense of smell early on. Third, conduct induced sleep monitoring, since some patients may have prominent sleep disorders. Additionally, it is suggested to perform striatal dopaminergic transporter imaging, a type of DAT scan. Although this scan is quite expensive, it can clearly reflect the function of the striatum.

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Early symptoms of Parkinson's disease.

Parkinson's disease is a relatively common degenerative disease in the elderly, primarily causing the death of dopamine neurons in the substantia nigra of the midbrain, leading to corresponding clinical manifestations. Research has confirmed that other systems may also be damaged in the early stages of Parkinson's disease symptoms. The early symptoms may primarily include: First, patients experience persistent constipation, which is a very important early symptom of Parkinson's disease. Second, some patients may experience sleep disturbances, mainly characterized by tossing and turning, shouting out loud during sleep, without being aware of it. Additionally, some patients in the early stages may also experience a reduced sense of smell, constipation, cognitive impairment, and other clinical manifestations. There are also some early motor symptoms, mainly that the patient becomes clumsy and inflexible in the movements of one side of the body. These are the early symptoms of Parkinson's disease.

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Written by Zhang Hui
Neurology
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What is needed to diagnose Parkinson's disease?

The definitive diagnosis of Parkinson's disease primarily relies on the patient's medical history, clinical manifestations, and a thorough physical examination by a neurologist. If the onset of the disease is very slow, presenting with symptoms such as bradykinesia and tremors, and the neurologist observes heightened muscle tone and slow movements during the examination, a high suspicion of this disease is warranted. Additionally, certain auxiliary tests are necessary, commonly including: First, testing the patient's sense of smell is crucial, as a reduced sense of smell is very important in diagnosing Parkinson's disease. Second, some brain MRI scans are needed mainly to exclude some secondary Parkinson's syndromes. Third, a brain PET-CT scan can be performed to examine the functionality of the striatum. Furthermore, an ultrasound of the substantia nigra in the midbrain can also be conducted, which holds significant value in assisting the diagnosis.

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Written by Zhang Hui
Neurology
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What department should Parkinson's disease go to?

Parkinson's disease is classified as a neurological disorder, so once considered for Parkinson's disease, registration is naturally in the department of neurology. Many neurologists are very familiar with Parkinson's disease and also have rich experience in diagnosis and treatment. Especially some neurology experts who specialize in Parkinson's disease have their own unique views on the pathogenesis, etiology, and clinical manifestations of the disease. Parkinson's disease is a chronic, degenerative neurological condition primarily divided into motor symptoms and non-motor symptoms, severely impacting the quality of life and work of patients. Symptoms include bradykinesia, resting tremor, muscle rigidity, etc. Treatment involves anticholinergic drugs and dopamine receptor agonists. (Note: This answer is for reference only. Medication should be administered under the guidance of a professional physician, and self-medication should be avoided.)