Atrial septal defect is a type of congenital heart disease. It is advised that patients avoid long-distance travel or running as these activities can increase the burden on the heart and also increase myocardial oxygen consumption. Surgical treatment is recommended for this condition. Patients with atrial septal defect may also experience symptoms such as palpitations and chest tightness, and a murmur can be heard in the precordial area. If the symptoms are severe, it is recommended that the patient primarily rests and avoids participating in sports activities, especially running. Running can require a lot of oxygen, or cause a rapid heart rate. A rapid heart rate can lead to increased myocardial oxygen consumption and may result in compensatory symptoms like palpitations, chest tightness, and shortness of breath. This situation is very dangerous and needs to be dealt with promptly; it is best to go to the hospital.