Patients with chronic renal failure who experience coughing should first analyze whether it is caused by an infection. In such cases, routine blood tests and chest CT scans are needed to confirm whether there are any infectious lesions in the lungs. Additionally, it should be checked whether the patient has systemic lupus erythematosus, vasculitis, or other conditions, as these diseases can affect the lungs and cause pulmonary lesions leading to coughing. Therefore, treatment should be targeted based on the cause. If the cough is due to an infection, antibiotics are required, but the dosage must be adjusted according to the patient's kidney function. If the cough is due to pulmonary changes caused by a systemic disease, targeted treatment for the systemic disease is needed.