Early symptoms of diabetic nephropathy

Written by Hu Lin
Nephrology
Updated on April 25, 2025
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The early symptoms of diabetic nephropathy primarily include the presence of microalbuminuria, which is characterized by an albumin excretion rate of 30 to 300 mg per 24 hours, or a ratio of albumin to creatinine in spot urine ranging from 30 to 300 mg/g. However, this value needs to be tested three times over six months, with at least two of these tests meeting the above criteria for a diagnosis. Additionally, in the early stages of diabetes, patients' blood pressure tends to be within the normal range, but there is a trend toward elevation. Some patients may experience changes in the diurnal rhythm of their blood pressure, and the glomerular filtration rate may slightly increase or remain within the normal range.

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Written by Zhang Jun Jun
Endocrinology
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What should I do if diabetic nephropathy causes facial swelling?

Diabetic nephropathy with facial swelling is generally due to too much protein in the urine and too little protein in the blood, causing hypoalbuminemia, which leads to edema. There are several methods to control diabetic nephropathy: First, blood sugar and blood pressure must be strictly controlled within a normal range. Blood pressure control should be even stricter for those with diabetic nephropathy, generally kept below 130/80. Second, in terms of diet, it is crucial to avoid or limit intake of bean-based foods and consume high-quality proteins instead. High-quality proteins include commonly known meats, eggs, and fish. Third, it is essential to limit or avoid the use of medications that can damage the kidneys. Fourth, if diabetic nephropathy causes general body edema, intermittent use of diuretic medications can help alleviate the swelling, along with nephroprotective medications. The final method for severe kidney disease involves early intervention with hemodialysis or peritoneal dialysis. (Please use medications under the guidance of a doctor)

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Written by Zhou Qi
Nephrology
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Can diabetic nephropathy cause blood in urine?

Generally speaking, diabetic nephropathy does not cause hematuria. The main site of damage in diabetic nephropathy is indeed the glomerulus. Prolonged hyperglycemia and metabolic disorders can lead to damage to the capillaries of the glomerulus. However, the main clinical characteristic of this damage is proteinuria, which causes glomerulosclerosis and may also lead to renal failure, but it is rare for patients to have red blood cells in their urine or to experience hematuria. Therefore, if a patient with diabetic nephropathy has visible hematuria, such as red or tea-colored urine, it is necessary to check for other causes beyond diabetes, such as urinary tract infections, urogenital system stones, tumors, etc., all of which can cause hematuria.

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Written by Zhou Qi
Nephrology
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Is diabetic nephropathy with facial swelling serious?

Patients with diabetic nephropathy who experience facial swelling should not use this symptom as a basis for judging the severity of their condition. Diabetic nephropathy is divided into five stages. The condition is relatively mild during the first three stages. By the fourth stage, patients begin to exhibit significant proteinuria, and by the fifth stage, they experience severe renal failure. Conditions in these last two stages are quite severe. However, patients might also experience facial swelling during the first three stages, and while the likelihood of facial swelling increases during the fourth and fifth stages, some patients in these stages might not show obvious edema. Therefore, it is difficult to determine the severity of the condition based solely on swelling. Patients need to undergo 24-hour urinary protein quantification and blood tests to assess kidney function in order to judge the severity of their condition.

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Written by Zhou Qi
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Can diabetic nephropathy with swollen feet be treated?

Patients with diabetic nephropathy who experience swelling in their feet often have significant amounts of protein in their urine or may have already developed renal failure. While there are ways to manage foot swelling, the fundamental issues may not be resolved. For swelling, diuretics can be used to increase urine output. If diuretics are ineffective, hemodialysis may be employed to ultrafiltrate and remove excess fluid from the body and alleviate swelling. However, these measures only address the symptoms on the surface. For patients with diabetic nephropathy, the underlying causes are due to diabetes, oxidative stress, and high blood sugar states, which damage the kidneys. Currently, there is no specific clinical treatment for these fundamental issues.

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Written by Luo Han Ying
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Is early diabetic nephropathy reversible?

Diabetic nephropathy clinically mainly manifests as an increase in urine protein on routine urine tests. Thus, diabetic nephropathy can be classified into different stages. In the early stages, microalbuminuria appears, and at this early phase, diabetic nephropathy is actually reversible. However, if the condition progresses with significant proteinuria, it becomes difficult to reverse diabetic nephropathy through intervention treatments. Most clinical patients may experience a slight reduction in urine protein or maintain this condition long-term without further progression. However, some patients have already experienced an increase in creatinine levels by the time they reach this stage of diabetic nephropathy, making it particularly challenging to reverse the condition once creatinine levels rise. Therefore, for diabetic nephropathy, early detection and treatment are crucial, with the most important goal being the prevention of the disease's onset.