During the acute phase, it is important to rest, drink plenty of water, urinate frequently, and provide a diet that is easy to digest, high in calories, and rich in vitamins for patients with fever. For patients with evident bladder irritation symptoms and significant hematuria, oral sodium bicarbonate can be taken to alkalize the urine and relieve symptoms. The primary treatment for acute pyelonephritis, of course, is anti-infection therapy. The pathogen in 80% of acute pyelonephritis cases is Escherichia coli. After collecting urine samples for bacterial examination, treatment should be initiated. For patients with milder conditions, outpatient oral medication can suffice, with a treatment duration of 10 to 14 days. Common medications include ofloxacin, amoxicillin, and cephalosporins, among others. Secondly, for severe infections accompanied by obvious systemic toxic symptoms, hospitalization for intravenous medication is required. Commonly chosen drugs include ampicillin, cefotaxime sodium, ceftriaxone sodium, and levofloxacin, etc. If the patient improves following the above treatments, they can switch to oral therapy after fever cessation and continue with a drip for three more days to complete a two-week course of treatment. (Please use medications under the guidance of a doctor; do not self-medicate.)