How to deal with swollen feet in IgA nephropathy?

Written by Zhou Qi
Nephrology
Updated on January 28, 2025
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IgA nephropathy is a pathological type of chronic glomerulonephritis, and patients are prone to edema. The treatment of this edema is divided into two aspects: First, it is necessary to control the condition of IgA nephropathy itself. If there is a significant amount of proteinuria or a large formation of crescents in the glomeruli, the patient may need to use steroids and immunosuppressive agents to control the inflammatory response in the glomeruli. This is the fundamental approach to treating this disease. Second, symptomatic treatment is applied. For mild edema, no special treatment is generally required. However, for severe edema or even systemic edema, it may be appropriate to use diuretics to increase urine output, which can alleviate the patient's edema. However, this is not a solution to the root cause of the problem.

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Written by Zhou Qi
Nephrology
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Can patients with IgA nephropathy have sexual intercourse?

Patients with IgA nephropathy can engage in sexual intercourse, but there are certain prerequisites. Firstly, this disease is not contagious, and it will not be transmitted to the partner during intercourse. Secondly, there is not a significant relationship between renal function and sexual capability; patients with kidney diseases typically retain normal sexual and reproductive functions. However, since sexual activity requires a certain amount of physical strength, and in cases where the patient's condition is particularly severe, it might render the patient unable to engage in sexual activities. Therefore, if the patient does not have significant hypertension, severe edema, especially genital edema, pulmonary edema, or heart failure, they would be capable of engaging in sexual activities, and thus can have intercourse.

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Written by Zhou Qi
Nephrology
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IgA kidney disease causes

IgA nephropathy is a type of chronic nephritis. Patients with this disease have inflammatory reactions within their glomeruli. This inflammation is caused by the deposition of IgA immune complexes in the glomeruli. The reason why patients are prone to IgA immune complex deposition is still not very clearly explained in current medical literature and remains unclear. It is possible that such patients produce defective IgA immunoglobulins, often related to mucosal inflammatory infections, such as tonsillitis, enteritis, proctitis, etc. Inflammation of these mucosal areas might cause defective secretory IgA to circulate through the bloodstream to the kidneys, triggering an inflammatory response. The production of defective IgA immunoglobulins in patients may be related to genetic and environmental factors, but the specific mechanism is still not very clear.

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Written by Li Liu Sheng
Nephrology
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How is IgA nephropathy caused?

IgA nephropathy is a common glomerular disease and a major cause of uremia. However, the exact cause of IgA nephropathy is not very clear. Current research suggests that it is caused by factors such as infections which stimulate the production of autoantibodies, forming immune complexes that deposit in the glomeruli. This leads to inflammation of the glomeruli, eventually stimulating mesangial cell proliferation and accumulation of extracellular matrix, causing glomerulosclerosis and interstitial fibrosis. IgA nephropathy is a very covert disease, often presenting as asymptomatic hematuria or increased urine protein. Many patients discover this condition incidentally during physical examinations. Some individuals have a history of upper respiratory or gastrointestinal infections before the onset of the disease, followed by the discovery of gross hematuria. IgA nephropathy is more common in children and adolescents.

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Written by Zhou Qi
Nephrology
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Causes of hematuria in IgA nephropathy

IGA nephropathy is a type of chronic glomerulonephritis. This disease often causes patients to have blood in their urine, and can also lead to visible blood in the urine. The glomerulus is a cluster of capillaries with semi-permeable functions, allowing water and metabolic waste to pass through while preventing proteins and red blood cells from passing. The waste and water pass through the glomerular filtration barrier and enter into the urine, which is the main component of urine. If some pathological cause damages the capillaries of the glomerulus, such as in the case of IGA nephropathy where there is an inflammatory response within the glomerulus, it can damage the glomerular filtration barrier. As a result, red blood cells may pass through the capillary walls of the glomerulus into the urine, causing blood in the urine.

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Written by Zhou Qi
Nephrology
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Can IgA nephropathy patients eat watermelon?

IgA nephropathy is a chronic glomerulonephritis with varying degrees of severity and diverse clinical manifestations. Whether patients can eat watermelon depends on their kidney function and the presence of edema symptoms. If patients have kidney failure and noticeable edema, it is advised that they avoid eating watermelon, as it contains a significant amount of potassium ions. Consuming watermelon may lead to hyperkalemia due to the intake of large amounts of potassium ions. The main component of watermelon is water, and if patients have noticeable symptoms of edema, eating watermelon may exacerbate these symptoms and even cause issues like hypertension. If patients do not have noticeable edema and their kidney function is normal, eating small amounts of watermelon should not be a major concern.